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  1. Review

    Tumor-augmenting effects of gestational arsenic exposure on F1 and F2 in mice

    The consequences of early-life exposure to chemicals in the environment are emerging concerns. Chronic exposure to naturally occurring inorganic arsenic has been known to cause various adverse health effects, ...

    Keiko Nohara, Takehiro Suzuki, Kazuyuki Okamura, Junya Matsushita and Shota Takumi

    Genes and Environment 2017 39:3

    Published on: 1 March 2017

  2. Letter to the Editor

    The 10th anniversary of the publication of genes and environment: memoir of establishing the Japanese environmental mutagen society and a proposal for a new collaborative study on mutagenic hormesis

    The Japanese Environmental Mutagen Society (JEMS) was established in 1972 by 147 members, 11 of whom are still on the active list as of May 1, 2016. As one of them, I introduce some historic topics here. These...

    Shizuyo Sutou

    Genes and Environment 2017 39:9

    Published on: 1 March 2017

  3. Letter to the Editor

    Evolution of genotoxicity test methods in Japan

    The evolution of methods to assess genotoxicity of test compounds is thought to be one of the important subjects in The Japanese Environmental and Mutagen Society (JEMS). In 1970, the Ministry of Education of...

    Toshio Sofuni

    Genes and Environment 2017 39:15

    Published on: 21 February 2017

  4. Review

    Transgenic rat models for mutagenesis and carcinogenesis

    Rats are a standard experimental animal for cancer bioassay and toxicological research for chemicals. Although the genetic analyses were behind mice, rats have been more frequently used for toxicological resea...

    Takehiko Nohmi, Kenichi Masumura and Naomi Toyoda-Hokaiwado

    Genes and Environment 2017 39:11

    Published on: 1 February 2017

  5. Research

    Genetic polymorphisms of human cytochrome P450 CYP1A1 in an Egyptian population and tobacco-induced lung cancer

    Cytochrome P450 CYP1A1 helps detoxify the potential carcinogens in tobacco smoke, it was reported that polymorphisms in the coding gene result in variation in the expression and activity levels which alter met...

    Nada Ezzeldin, Dalia El-Lebedy, Amira Darwish, Ahmed El-Bastawisy, Mirhane Hassan, Shereen Abd El-Aziz, Mohamed Abdel-Hamid and Amal Saad-Hussein

    Genes and Environment 2017 39:7

    Published on: 7 January 2017

  6. Research

    DNA polymerase kappa protects human cells against MMC-induced genotoxicity through error-free translesion DNA synthesis

    Interactions between genes and environment are critical factors for causing cancer in humans. The genotoxicity of environmental chemicals can be enhanced via the modulation of susceptible genes in host human c...

    Yuki Kanemaru, Tetsuya Suzuki, Akira Sassa, Kyomu Matsumoto, Noritaka Adachi, Masamitsu Honma, Satoshi Numazawa and Takehiko Nohmi

    Genes and Environment 2017 39:6

    Published on: 7 January 2017

  7. Short report

    Absence of in vivo mutagenicity of multi-walled carbon nanotubes in single intratracheal instillation study using F344 gpt delta rats

    It is known that fibrous particles of micrometer length, such as carbon nanotubes, which have same dimensions as asbestos, are carcinogenic. Carcinogenicity of nanomaterials is strongly related to inflammatory...

    Katsuyoshi Horibata, Akiko Ukai, Akio Ogata, Dai Nakae, Hiroshi Ando, Yoshikazu Kubo, Akemichi Nagasawa, Katsuhiro Yuzawa and Masamitsu Honma

    Genes and Environment 2017 39:4

    Published on: 6 January 2017

  8. Commentary

    Genotoxicity assessment of 4-methylimidazole: regulatory perspectives

    4-Methylimidazole (4-MI) is formed as a result of the Maillard reaction process, and therefore is found in many foods and beverages. It is also found in soft drinks (i.e., cola) as a by-product in the producti...

    Takeshi Morita and Chikako Uneyama

    Genes and Environment 2016 38:20

    Published on: 1 November 2016

  9. Research

    Selective enhancing effect of metal ions on mutagenicity

    We investigated the enhancing effect of metal ions on several mutagens and examined their mechanism of action. We performed the Ames tests on six mutagens, i.e., 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide, 4-ni...

    Nobuyoshi Fujii, Shigemitsu Yano and Kenji Takeshita

    Genes and Environment 2016 38:21

    Published on: 1 November 2016

  10. Research

    Structural chromosome aberrations cause swelling of the nucleus

    Carcinogens are known to cause swelling of the mammalian cell nucleus. However, the mechanism of the swelling and its toxicological significance have not been fully elucidated. Since nuclear swelling (NS herea...

    Kenji Takeshita, Hiroaki I. Ogawa and Toshinari Maeda

    Genes and Environment 2016 38:22

    Published on: 1 October 2016

  11. Review

    Collaborative studies in toxicogenomics in rodent liver in JEMS·MMS; a useful application of principal component analysis on toxicogenomics

    Toxicogenomics is a rapidly developing discipline focused on the elucidation of the molecular and cellular effects of chemicals on biological systems. As a collaborative study group of Toxicogenomics/JEMS·MMS,...

    Chie Furihata, Takashi Watanabe, Takayoshi Suzuki, Shuichi Hamada and Madoka Nakajima

    Genes and Environment 2016 38:15

    Published on: 1 August 2016

  12. Review

    Oral environment and cancer

    Cancer is now the leading cause of death in Japan. A rapid increase in cancer mortality is expected as Japan is facing a super-aged society. Many causes of cancer are known to be closely linked to life style f...

    Yasusei Kudo, Hidesuke Tada, Natsumi Fujiwara, Yoshiko Tada, Takaaki Tsunematsu, Yoichiro Miyake and Naozumi Ishimaru

    Genes and Environment 2016 38:13

    Published on: 1 August 2016

  13. Reviewer acknowledgement

    Acknowledgement to reviewers

    The editors of Genes and Environment would like to thank all our reviewers who have contributed to the journal in Volume XXXVII (2015).

    Takashi Yagi

    Genes and Environment 2016 39:1

    Published on: 22 June 2016

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