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Table 4 Genotype and minor allele frequencies and Hardy Weinberg equilibrium for the selected TLR4 polymorphisms comparing children with uncomplicated and severe malaria

From: Toll-like receptor (TLR4) Asp299Gly and Thr399Ile polymorphisms in relation to clinical falciparum malaria among Nigerian children: a multisite cross-sectional immunogenetic study in Lagos

TLR4 SNP Genotype/Minor allele Study group OR (95 % CI) P HWE, χ2 (P)
Total SM UM
(N = 187) (n = 17) (n = 170)
Asp299Gly Asp299Asp, % (Fraction) 87.7 (164/187) 70.6 (12/17) 89.4(152/170) 1   SM = 0.21 (>0.05)
Asp299Gly, % (Fraction) 10.7 (20/187) 23.5 (4/17) 9.4 (16/170)    
Gly299Gly, % (Fraction) 1.6 (3/187) 5.9 (1/17) 1.2 (2/170) 3.12 (1.11-11.12) 0.02 UM = 1.47 (>0.05)
MAF 7 (26/374) 17.6(6/34) 5.9 (20/340)   0.01  
Thr399Ile Thr399Thr, % (Fraction) 94.7 (177/187) 76.5 (13/17) 96.5 (164/170) 1   SM = 0.25 (>0.05)
Thr399Ile, % (Fraction) 4.3 (8/187) 17.6 (3/17) 2.9 (5/170)    
Ile399Ile, % (Fraction) 1.0 (2/187) 5.9 (1/17) 0.6 (1/170) 8.4 (2.1-33.6) 0.0005 UM = 0.59 (>0.05)
MAF, % (Fraction) 3.2 (12/374) 14.7 (5/34) 2.1 (7/340)   0.00007  
  1. MAF = Minor allele frequency, OR = odd ratio, 95 % CI = 95 % confidence intervals, n = number of children screened per sub-group; N = total number of children screened. *OR was calculated after pooling heterozygous and homozygous mutant genotype frequencies; SM = Severe malaria; UM = Uncomplicated malaria; P < 0.05 was considered to be significant