|
TLR4 SNP
|
Genotype/Minor allele
|
Study group
|
OR (95 % CI)
|
P
|
HWE, χ2 (P)
|
|---|
|
Total
|
SM
|
UM
|
|---|
|
(N = 187)
|
(n = 17)
|
(n = 170)
|
|---|
|
Asp299Gly
|
Asp299Asp, % (Fraction)
|
87.7 (164/187)
|
70.6 (12/17)
|
89.4(152/170)
|
1
| |
SM = 0.21 (>0.05)
|
|
Asp299Gly, % (Fraction)
|
10.7 (20/187)
|
23.5 (4/17)
|
9.4 (16/170)
| | | |
|
Gly299Gly, % (Fraction)
|
1.6 (3/187)
|
5.9 (1/17)
|
1.2 (2/170)
|
3.12 (1.11-11.12)
|
0.02
|
UM = 1.47 (>0.05)
|
|
MAF
|
7 (26/374)
|
17.6(6/34)
|
5.9 (20/340)
| |
0.01
| |
|
Thr399Ile
|
Thr399Thr, % (Fraction)
|
94.7 (177/187)
|
76.5 (13/17)
|
96.5 (164/170)
|
1
| |
SM = 0.25 (>0.05)
|
|
Thr399Ile, % (Fraction)
|
4.3 (8/187)
|
17.6 (3/17)
|
2.9 (5/170)
| | | |
|
Ile399Ile, % (Fraction)
|
1.0 (2/187)
|
5.9 (1/17)
|
0.6 (1/170)
|
8.4 (2.1-33.6)
|
0.0005
|
UM = 0.59 (>0.05)
|
|
MAF, % (Fraction)
|
3.2 (12/374)
|
14.7 (5/34)
|
2.1 (7/340)
| |
0.00007
| |
- MAF = Minor allele frequency, OR = odd ratio, 95 % CI = 95 % confidence intervals, n = number of children screened per sub-group; N = total number of children screened. *OR was calculated after pooling heterozygous and homozygous mutant genotype frequencies; SM = Severe malaria; UM = Uncomplicated malaria; P < 0.05 was considered to be significant
