Table 4 Genotype and minor allele frequencies and Hardy Weinberg equilibrium for the selected TLR4 polymorphisms comparing children with uncomplicated and severe malaria
TLR4 SNP | Genotype/Minor allele | Study group | OR (95 % CI) | P | HWE, χ2 (P) | ||
|---|---|---|---|---|---|---|---|
Total | SM | UM | |||||
(N = 187) | (n = 17) | (n = 170) | |||||
Asp299Gly | Asp299Asp, % (Fraction) | 87.7 (164/187) | 70.6 (12/17) | 89.4(152/170) | 1 |  | SM = 0.21 (>0.05) |
Asp299Gly, % (Fraction) | 10.7 (20/187) | 23.5 (4/17) | 9.4 (16/170) | Â | Â | Â | |
Gly299Gly, % (Fraction) | 1.6 (3/187) | 5.9 (1/17) | 1.2 (2/170) | 3.12 (1.11-11.12) | 0.02 | UM = 1.47 (>0.05) | |
MAF | 7 (26/374) | 17.6(6/34) | 5.9 (20/340) | Â | 0.01 | Â | |
Thr399Ile | Thr399Thr, % (Fraction) | 94.7 (177/187) | 76.5 (13/17) | 96.5 (164/170) | 1 |  | SM = 0.25 (>0.05) |
Thr399Ile, % (Fraction) | 4.3 (8/187) | 17.6 (3/17) | 2.9 (5/170) | Â | Â | Â | |
Ile399Ile, % (Fraction) | 1.0 (2/187) | 5.9 (1/17) | 0.6 (1/170) | 8.4 (2.1-33.6) | 0.0005 | UM = 0.59 (>0.05) | |
MAF, % (Fraction) | 3.2 (12/374) | 14.7 (5/34) | 2.1 (7/340) | Â | 0.00007 | Â | |