Table 5 Associations between TLR4 Asp299Gly and Thr399Ile polymorphisms and malaria outcomes, in children with clinical malaria

Anaemia

TLR4 Asp299Gly polymorphism

Asp299Asp

28/164

1

1

Asp299Gly + Gly299Gly

9/23

3.12 (1.12 – 8.67) 0.01

2.87 (1.02 – 7.98), 0.02

TLR4 Thr399Ile polymorphism

Thr399Thr

31/177

1

1

Thr399Ile + Ile399Ile

6/10

7.06 (1.63 -32.1), 0.001

6.63 (1.53 – 30.15), 0.002

Severe Anaemia TLR4 Asp299Gly polymorphism

Asp299Asp

10/164

1

1

Asp299Gly + Gly299Gly

5/23

4.28 (1.12 – 15.8), 0.009

3.81 (1.07 – 13.1), 0.01

TLR4 Thr399Ile polymorphism

Thr399Thr

12/177

1

1

Thr399Ile + Ile399Ile

3 /10

5.89 (1.05 – 30.55), 0.0085

5.25 (0.93 – 27.3), 0.02

Malnutrition (WHZ or WAZ or HAZ < −2) TLR4 Asp299Gly polymorphism

Asp299Asp

34/164

1

1

Asp299Gly + Gly299Gly

8/23

2.04 (0.72 – 5.67), 0.13

1.93 (0.68 – 5.37), 0.16

TLR4 Thr399Ile polymorphism

Thr399Thr

39/177

1

Thr399Ile + Ile399Ile

3/10

1.1.52 (0.29 -6.95), 0.56

1.37 (0.27 – 6.31), 0.66

Severe malnutrition (WHZ; WAZ or HAZ < −3)

TLR4 Asp299Gly polymorphism

Asp299Asp

10/97

1

1

Asp299Gly + Gly299Gly

4/12

3.87 (0.82 – 17.67), 0.037

3.70 (0.76 – 17.4), 0.05

TLR4 Thr399Ile polymorphism

Thr399Thr

12/100

1

1

Thr399Ile + Ile399Ile

2/9

2.11 (0.27 – 13.26), 0.38

1.79 (0.23 – 11.34), 0.43

High Parasite density

TLR4 Asp299Gly polymorphism

1

1

Asp299Asp

46/164

5.86 (2.09 – 16.96), 0.0007

3.54 (1.19 – 10.76), 0.009

Asp299Gly + Gly299Gly

16/23

TLR4 Thr399Ile polymorphism

Thr399Thr

55/177

1

1

Thr399Ile + Ile399Ile

7/10

5.18 (1.15 – 26.38), 0.01

4.41 (0.97 – 22.54), 0.02

Fever TLR4 Asp299Gly polymorphism

Asp299Asp

48/164

1

1

Asp299Gly + Gly299Gly

10/23

1.86 (0.70 – 4.92), 0.16

0.88 (0.36 – 2.13), 0.76

TLR4 Thr399Ile polymorphism

Thr399Thr

52/177

1

1

Thr399Ile + Ile399Ile

6/10

3.61 (0.05 – 15.99), 0.04

4.27 (1.01 – 18.89), 0.02