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Table 5 Associations between TLR4 Asp299Gly and Thr399Ile polymorphisms and malaria outcomes, in children with clinical malaria

From: Toll-like receptor (TLR4) Asp299Gly and Thr399Ile polymorphisms in relation to clinical falciparum malaria among Nigerian children: a multisite cross-sectional immunogenetic study in Lagos

Associationa Prevalence % (fraction) OR, 95 % CI, P
Unadjusted Adjustedb
Anaemia    
TLR4 Asp299Gly polymorphism    
Asp299Asp 28/164 1 1
Asp299Gly + Gly299Gly 9/23 3.12 (1.12 – 8.67) 0.01 2.87 (1.02 – 7.98), 0.02
TLR4 Thr399Ile polymorphism    
Thr399Thr 31/177 1 1
Thr399Ile + Ile399Ile 6/10 7.06 (1.63 -32.1), 0.001 6.63 (1.53 – 30.15), 0.002
Severe Anaemia TLR4 Asp299Gly polymorphism    
Asp299Asp 10/164 1 1
Asp299Gly + Gly299Gly 5/23 4.28 (1.12 – 15.8), 0.009 3.81 (1.07 – 13.1), 0.01
TLR4 Thr399Ile polymorphism    
Thr399Thr 12/177 1 1
Thr399Ile + Ile399Ile 3 /10 5.89 (1.05 – 30.55), 0.0085 5.25 (0.93 – 27.3), 0.02
Malnutrition (WHZ or WAZ or HAZ < −2) TLR4 Asp299Gly polymorphism    
Asp299Asp 34/164 1 1
Asp299Gly + Gly299Gly 8/23 2.04 (0.72 – 5.67), 0.13 1.93 (0.68 – 5.37), 0.16
TLR4 Thr399Ile polymorphism    
Thr399Thr 39/177   1
Thr399Ile + Ile399Ile 3/10 1.1.52 (0.29 -6.95), 0.56 1.37 (0.27 – 6.31), 0.66
Severe malnutrition (WHZ; WAZ or HAZ < −3)    
TLR4 Asp299Gly polymorphism    
Asp299Asp 10/97 1 1
Asp299Gly + Gly299Gly 4/12 3.87 (0.82 – 17.67), 0.037 3.70 (0.76 – 17.4), 0.05
TLR4 Thr399Ile polymorphism    
Thr399Thr 12/100 1 1
Thr399Ile + Ile399Ile 2/9 2.11 (0.27 – 13.26), 0.38 1.79 (0.23 – 11.34), 0.43
High Parasite density    
TLR4 Asp299Gly polymorphism   1 1
Asp299Asp 46/164 5.86 (2.09 – 16.96), 0.0007 3.54 (1.19 – 10.76), 0.009
Asp299Gly + Gly299Gly 16/23   
TLR4 Thr399Ile polymorphism    
Thr399Thr 55/177 1 1
Thr399Ile + Ile399Ile 7/10 5.18 (1.15 – 26.38), 0.01 4.41 (0.97 – 22.54), 0.02
Fever TLR4 Asp299Gly polymorphism    
Asp299Asp 48/164 1 1
Asp299Gly + Gly299Gly 10/23 1.86 (0.70 – 4.92), 0.16 0.88 (0.36 – 2.13), 0.76
TLR4 Thr399Ile polymorphism    
Thr399Thr 52/177 1 1
Thr399Ile + Ile399Ile 6/10 3.61 (0.05 – 15.99), 0.04 4.27 (1.01 – 18.89), 0.02
  1. OR = Odd ratio; 95 % CI = 95 % confidence interval; aDominant model of inheritance of the TLR4 genotypes was used for the analysis of their association with the disease phenotypes: anaemia, severe anaemia, malnutrition, severe malnutrition, high parasite density and fever. bOR (95 % CI) adjustment was according to age and gender; P < 0.05 was taken as significant