Skip to main content

Table 1 Mutant frequencies in B[a]P-instilled and control lung of gpt delta mice

From: Alterations in the mutagenicity and mutation spectrum induced by benzo[a]pyrene instilled in the lungs of gpt delta mice of various ages

B[a]P

Time

ID of animals

Number of colonies

Mutant frequency

Average mutant frequency ± SD

(mg)

(months)

 

Mutant

Total

(×10−5)

(×10−5)

0

3

1a

5

800,800

0.62

 
  

2a

5

1,113,600

0.45

 
  

3a

5

702,400

0.71

 
  

4b

3

441,600

0.68

 
  

5b

3

643,200

0.47

 
  

6b

3

828,000

0.36

 
  

7c

7

1,016,000

0.69

 
  

8c

6

836,800

0.72

 
  

9c

3

524,200

0.57

 
  

Total

40

6,906,600

 

0.59 ± 0.13

 

11

1

3

311,000

0.96

 
  

2

5

530,000

0.94

 
  

3

30

2,389,000

1.26

 
  

4

28

1,915,000

1.46

 
  

5

34

3,117,000

1.09

 
  

Total

100

8,262,000

 

1.14 ± 0.22††

 

24

1

12

1,408,000

0.85

 
  

2

18

1,464,000

1.23

 
  

3

14

1,548,000

0.90

 
  

Total

44

4,420,000

 

1.00 ± 0.20

1

3

1 a

11

499,200

2.20

 
  

2 a

14

556,800

2.51

 
  

3 a

35

1,225,600

2.86

 
  

Total

60

2,281,600

 

2.52 ± 0.33**

 

11

1

11

750,000

1.47

 
  

2

13

700,000

1.86

 
  

3

14

738,000

1.90

 
  

4

17

1,061,000

1.60

 
  

5

27

1,728,000

1.56

 
  

Total

82

4,977,000

 

1.68 ± 0.19*,††

 

24

1

13

456,000

2.85

 
  

2

36

1,996,000

1.80

 
  

3

17

809,000

2.10

 
  

Total

66

3,261,000

 

2.25 ± 0.54*,

  1. *P < 0.01, **P < 0.001 for comparison between B[a]P-instilled mice and age-matched control mice
  2. P < 0.01, †† P < 0.001 for comparison to equivalently treated 3-month–old mice
  3. a, b and cData from our previous studies ([11, 17, 18], respectively)