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Table 1 Mutant frequencies in B[a]P-instilled and control lung of gpt delta mice

From: Alterations in the mutagenicity and mutation spectrum induced by benzo[a]pyrene instilled in the lungs of gpt delta mice of various ages

B[a]P Time ID of animals Number of colonies Mutant frequency Average mutant frequency ± SD
(mg) (months)   Mutant Total (×10−5) (×10−5)
0 3 1a 5 800,800 0.62  
   2a 5 1,113,600 0.45  
   3a 5 702,400 0.71  
   4b 3 441,600 0.68  
   5b 3 643,200 0.47  
   6b 3 828,000 0.36  
   7c 7 1,016,000 0.69  
   8c 6 836,800 0.72  
   9c 3 524,200 0.57  
   Total 40 6,906,600   0.59 ± 0.13
  11 1 3 311,000 0.96  
   2 5 530,000 0.94  
   3 30 2,389,000 1.26  
   4 28 1,915,000 1.46  
   5 34 3,117,000 1.09  
   Total 100 8,262,000   1.14 ± 0.22††
  24 1 12 1,408,000 0.85  
   2 18 1,464,000 1.23  
   3 14 1,548,000 0.90  
   Total 44 4,420,000   1.00 ± 0.20
1 3 1 a 11 499,200 2.20  
   2 a 14 556,800 2.51  
   3 a 35 1,225,600 2.86  
   Total 60 2,281,600   2.52 ± 0.33**
  11 1 11 750,000 1.47  
   2 13 700,000 1.86  
   3 14 738,000 1.90  
   4 17 1,061,000 1.60  
   5 27 1,728,000 1.56  
   Total 82 4,977,000   1.68 ± 0.19*,††
  24 1 13 456,000 2.85  
   2 36 1,996,000 1.80  
   3 17 809,000 2.10  
   Total 66 3,261,000   2.25 ± 0.54*,
  1. *P < 0.01, **P < 0.001 for comparison between B[a]P-instilled mice and age-matched control mice
  2. P < 0.01, †† P < 0.001 for comparison to equivalently treated 3-month–old mice
  3. a, b and cData from our previous studies ([11, 17, 18], respectively)