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Table 2 Classification of gpt mutations from the lung of B[a]P-instilled and control mice

From: Alterations in the mutagenicity and mutation spectrum induced by benzo[a]pyrene instilled in the lungs of gpt delta mice of various ages

Type of mutation in the gpt gene Control B[a]P Control (months) B[a]P (months)
All ages All ages 3a 11 24 3b 11 24
  Number % Number % Number % Number % Number % Number % Number % Number %
Base substitution                 
Transition                 
G:C → A:T 68 39 44 26 17 45 36 39 15 35 4 10 20 25 20 41
(at CpG site) (28) (16) (20) (12) (7) (18) (14) (15) (7) (16) (1) (2) (11) (13) (8) (16)
A:T → G:C 14 8 1 1 3 8 10 11 1 2 0 0 0 0 1 2
Transversion                 
G:C → T:A 29 17 51 30 8 21 15 16 6 14 23 55 19 24 9 18
(at CpG site) (6) (3) (33) (19) (3) (8) (3) (3) (1) (2) (19) (45) (8) (10) (6) (12)
G:C → C:G 12 7 22 13 6 16 4 4 2 5 7 17 12 15 3 6
A:T → T:A 12 7 7 4 1 3 6 7 5 12 0 0 4 5 3 6
A:T → C:G 7 4 3 2 0 0 4 4 3 7 0 0 0 0 3 6
Deletion                 
−1 18 10 22 13 3 8 9 10 6 14 4 10 14 18 4 8
>2 6 3 5 3 0 0 2 2 4 9 0 0 2 3 3 6
Insertion 6 3 11 6 0 0 5 5 1 2 2 5 6 8 3 6
Other 1 1 4 2 0 0 1 1 0 0 2 5 2 3 0 0
Total 173 100 170 100 38 100 92 100 43 100 42 100 79 100 49 100
  1. aCombined data of our previous studies [11, 17, 18]
  2. bOur previous data [11]
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Genes and Environment

ISSN: 1880-7062

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