Alterations in the mutagenicity and mutation spectrum induced by benzo[a]pyrene instilled in the lungs of gpt delta mice of various ages

Table 2 Classification of gpt mutations from the lung of B[a]P-instilled and control mice

Type of mutation in the gpt gene	Control		B[a]P		Control (months)						B[a]P (months)
Type of mutation in the gpt gene	All ages		All ages		3^a		11		24		3^b		11		24
	Number	%	Number	%	Number	%	Number	%	Number	%	Number	%	Number	%	Number	%
Base substitution
Transition
G:C → A:T	68	39	44	26	17	45	36	39	15	35	4	10	20	25	20	41
(at CpG site)	(28)	(16)	(20)	(12)	(7)	(18)	(14)	(15)	(7)	(16)	(1)	(2)	(11)	(13)	(8)	(16)
A:T → G:C	14	8	1	1	3	8	10	11	1	2	0	0	0	0	1	2
Transversion
G:C → T:A	29	17	51	30	8	21	15	16	6	14	23	55	19	24	9	18
(at CpG site)	(6)	(3)	(33)	(19)	(3)	(8)	(3)	(3)	(1)	(2)	(19)	(45)	(8)	(10)	(6)	(12)
G:C → C:G	12	7	22	13	6	16	4	4	2	5	7	17	12	15	3	6
A:T → T:A	12	7	7	4	1	3	6	7	5	12	0	0	4	5	3	6
A:T → C:G	7	4	3	2	0	0	4	4	3	7	0	0	0	0	3	6
Deletion
−1	18	10	22	13	3	8	9	10	6	14	4	10	14	18	4	8
>2	6	3	5	3	0	0	2	2	4	9	0	0	2	3	3	6
Insertion	6	3	11	6	0	0	5	5	1	2	2	5	6	8	3	6
Other	1	1	4	2	0	0	1	1	0	0	2	5	2	3	0	0
Total	173	100	170	100	38	100	92	100	43	100	42	100	79	100	49	100

ISSN: 1880-7062