Genotoxicity-suppressing effect of aqueous extract of Connarus ruber cortex on cigarette smoke-induced micronuclei in mouse peripheral erythrocytes

Table 2 Body weight in the mice during the period of exposure to cigarette smoke

Connarus extract (ppm)	Mortality within exposure period	Water or Connarus intake (mL/mouse/day)	Body weight (g, mean ± SD)
			Period of exposure to cigarette smoke (day)
			0	7	14
0^a	0/4	5.56	37.3 ± 0.83	38.3 ± 1.79	38.0 ± 1.41
0^b	0/4	6.25	36.8 ± 1.79	37.8 ± 2.49	38.3 ± 1.79
11.8^b	0/4	7.50	37.8 ± 1.30	37.8 ± 1.30	37.8 ± 1.30
23.7^b	0/4	6.25	37.3 ± 1.30	38.5 ± 1.66	38.5 ± 1.80
47.4^b	0/4	7.50	36.8 ± 1.10	37.5 ± 1.11	39.0 ± 1.22
94.8^b	0/4	6.25	37.8 ± 1.48	36.5 ± 1.12	37.8 ± 1.30
190^b	0/4	5.63	35.3 ± 1.63	37.8 ± 2.49	35.0 ± 1.58
379^b	0/4	6.25	35.5 ± 2.06	37.5 ± 2.69	35.5 ± 2.06
758^b	0/4	6.25	34.5 ± 1.50	37.8 ± 2.48	35.3 ± 1.09
758^a	0/4	6.61	35.3 ± 2.27	36.3 ± 0.83	36.5 ± 1.12

No clinical signs showing the toxicity of Connarus extract were observed
^aSham control group
^bMice were exposed for 1 min to a 5.85-fold dilution of the smoke once a day for up to 14 consecutive days

ISSN: 1880-7062