|
Connarus extract (ppm)
|
Mortality within exposure period
|
Water or Connarus intake (mL/mouse/day)
|
Body weight (g, mean ± SD)
|
|---|
|
Period of exposure to cigarette smoke (day)
|
|---|
|
0
|
7
|
14
|
|---|
|
0a
|
0/4
|
5.56
|
37.3 ± 0.83
|
38.3 ± 1.79
|
38.0 ± 1.41
|
|
0b
|
0/4
|
6.25
|
36.8 ± 1.79
|
37.8 ± 2.49
|
38.3 ± 1.79
|
|
11.8b
|
0/4
|
7.50
|
37.8 ± 1.30
|
37.8 ± 1.30
|
37.8 ± 1.30
|
|
23.7b
|
0/4
|
6.25
|
37.3 ± 1.30
|
38.5 ± 1.66
|
38.5 ± 1.80
|
|
47.4b
|
0/4
|
7.50
|
36.8 ± 1.10
|
37.5 ± 1.11
|
39.0 ± 1.22
|
|
94.8b
|
0/4
|
6.25
|
37.8 ± 1.48
|
36.5 ± 1.12
|
37.8 ± 1.30
|
|
190b
|
0/4
|
5.63
|
35.3 ± 1.63
|
37.8 ± 2.49
|
35.0 ± 1.58
|
|
379b
|
0/4
|
6.25
|
35.5 ± 2.06
|
37.5 ± 2.69
|
35.5 ± 2.06
|
|
758b
|
0/4
|
6.25
|
34.5 ± 1.50
|
37.8 ± 2.48
|
35.3 ± 1.09
|
|
758a
|
0/4
|
6.61
|
35.3 ± 2.27
|
36.3 ± 0.83
|
36.5 ± 1.12
|
- No clinical signs showing the toxicity of Connarus extract were observed
-
aSham control group
-
bMice were exposed for 1 min to a 5.85-fold dilution of the smoke once a day for up to 14 consecutive days
