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Fig. 1 | Genes and Environment

Fig. 1

From: Role of hepatic cytochrome P450 enzymes in the detoxication of aristolochic acid I; effects on DNA adduct, mutation, and tumor formation

Fig. 1

The balance between oxidative detoxication and reductive activation of aristolochic acid I (AAI). Detoxification of AAI by O-demethylation to generate AAIa, and bio-activation of AAI by nitroreduction to form DNA adducts including dA-AAI and dG-AAI. dA-AAI, 7-(deoxyadenosin-N6-yl) aristolactam I; dG-AAI, 7-(deoxyguanosin-N2-yl) aristolactam I; AAIa, 8-OH-aristolochic acid I

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