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Fig. 2 | Genes and Environment

Fig. 2

From: Role of hepatic cytochrome P450 enzymes in the detoxication of aristolochic acid I; effects on DNA adduct, mutation, and tumor formation

Fig. 2

The concentrations of AAI in plasma and tissues in BNF-pretreated WT mice, WT mice and HRN gpt delta mice. Upper panel is serum levels of AAI. Mice were intragastrically treated with AAI at a single dose of 15 mg/kg, tail vein blood samples were collected from individual mice at eight time points after dosing for determination of AAI concentrations as described in Materials and Methods. Inset: pharmacokinetic variables in mice. Values presented as mean ± SD, n = 4. *, p < 0.05, **, p < 0.01, compared to WT mice. MRT, Mean Residence Time. Lower is the concentrations of AAI in the liver and kidney of mice. B-WT, wild-type mice were pretreated with β-naphthoflavone (BNF). WT, wild-type mice. HRN, hepatic Reductase Null gpt delta mice. #, p < 0.05, ##, p < 0.01, the concentration of AAI in kidney compared to WT mice. *, p < 0.05, **, p < 0.01, the concentration of AAI in liver compared to WT mice. N = 4

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