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Table 1 Formation of AA-DNA adducts in the liver and kidney of gpt delta transgenic mice treated with AAI or AAII

From: Role of hepatic cytochrome P450 enzymes in the detoxication of aristolochic acid I; effects on DNA adduct, mutation, and tumor formation

AAI-derived DNA adducts dA-AAI dG-AAI Total
per 107 dN per 107 dN per 107 dN
Liver    
B-WT - - -
WT - - -
HRN 15.92 ± 4.46 10.38 ± 4.86 26.29 ± 9.22
Kidney    
B-WT 029.94 ± 11.46 24.02 ± 6.30 053.96 ± 16.52
WT 58.09 ± 9.50 68.68 ± 6.93 126.77 ± 12.28*
HRN 101.59 ± 45.30 152.15 ± 26.52 253.75 ± 38.08*
  1. B-WT wild-type mice were pretreated with β-naphthoflavone (BNF); WT wild-type mice, HRN hepatic Reductase Null gpt delta mice
  2. Values presented are mean ± SD, n = 5, dN, deoxynucleosides.*, p < 0.05 compare with WT mice. -, not detected
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Genes and Environment

ISSN: 1880-7062

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