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Table 1 Formation of AA-DNA adducts in the liver and kidney of gpt delta transgenic mice treated with AAI or AAII

From: Role of hepatic cytochrome P450 enzymes in the detoxication of aristolochic acid I; effects on DNA adduct, mutation, and tumor formation

AAI-derived DNA adducts

dA-AAI

dG-AAI

Total

per 107 dN

per 107 dN

per 107 dN

Liver

   

B-WT

-

-

-

WT

-

-

-

HRN

15.92 ± 4.46

10.38 ± 4.86

26.29 ± 9.22

Kidney

   

B-WT

029.94 ± 11.46

24.02 ± 6.30

053.96 ± 16.52

WT

58.09 ± 9.50

68.68 ± 6.93

126.77 ± 12.28*

HRN

101.59 ± 45.30

152.15 ± 26.52

253.75 ± 38.08*

  1. B-WT wild-type mice were pretreated with β-naphthoflavone (BNF); WT wild-type mice, HRN hepatic Reductase Null gpt delta mice
  2. Values presented are mean ± SD, n = 5, dN, deoxynucleosides.*, p < 0.05 compare with WT mice. -, not detected