Role of hepatic cytochrome P450 enzymes in the detoxication of aristolochic acid I; effects on DNA adduct, mutation, and tumor formation

Table 2 Number of neoplsia in WT mice and HRN gpt delta mice treated with AAI for two months

Organ	Tumor	4 months recovery			7 months recovery
Organ	Tumor	Con	WT	HRN	Con	WT	HRN
Forestomach	Papilloma with signs of malignancy	0	1	1		2	1
	Squamouse cell carcinoma	0	0	0		1	2
Duodenum	Adenoma	0	0	0		0	2
Mice with neoplasia		0/10	1/8	1/5	0/10	3/8	5/8

ISSN: 1880-7062