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Table 2 Number of neoplsia in WT mice and HRN gpt delta mice treated with AAI for two months

From: Role of hepatic cytochrome P450 enzymes in the detoxication of aristolochic acid I; effects on DNA adduct, mutation, and tumor formation

Organ Tumor 4 months recovery 7 months recovery
Con WT HRN Con WT HRN
Forestomach Papilloma with signs of malignancy 0 1 1   2 1
  Squamouse cell carcinoma 0 0 0   1 2
Duodenum Adenoma 0 0 0   0 2
Mice with neoplasia   0/10 1/8 1/5 0/10 3/8 5/8
  1. WT wild-type mice; HRN hepatic Reductase Null gpt delta mice