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Table 1 Summary of independent cII mutations in mammary gland and ovary of Big Blue transgenic mice exposed to E2 at the first 5 days of life and/or treated with DMBA at 6 months of age

From: Neonatal exposure of 17β-estradiol has no effects on mutagenicity of 7,12-dimethylbenz [a] anthracene in reproductive tissues of adult mice

Tissue Type of mutation Control E2a DMBAb E2 + DMBAc, d
Number % Number % Number % Number %
Mammary gland G:C → C:G 3 9 4 10 4 6 4 4
G:C → A:T 14 43 18 45 5 8 8 9
G:C → T:A 7 21 6 15 13 20 14 16
A:T → T:A 1 3 4 10 33 50 48 53
A:T → C:G 3 9 3 8 3 4 4 4
A:T → G:C 2 6 1 2 5 8 9 10
Frameshift 3 9 4 10 3 4 3 3
Tandem 0 0 0 0 0 0 1 1
Total mutants screened 33 100 40 100 66 100 91 100
Ovary G:C → C:G 2 5 2 8 11 11 13 11
G:C → A:T 16 42 11 44 12 12 19 17
G:C → T:A 9 24 6 24 22 23 20 17
A:T → T:A 3 8 1 4 37 38 37 33
A:T → C:G 1 3 1 4 5 5 6 5
A:T → G:C 2 5 0 0 9 9 10 9
Frameshift 5 13 4 16 2 2 7 6
Tandem 0 0 0 0 0 0 2 2
Total mutants screened 38 100 25 100 98 100 114 100
  1. aNo significant difference from control group
  2. bSpectrum from DMBA-treated mice was significantly different from control and E2-only groups (p < 0.0001)
  3. cSpectrum from the mice exposed to E2 and DMBA was significantly different from control and E2-only groups (p < 0.01 in ovary and p < 0.0001 in mammary gland)
  4. dNo significant difference from DMBA group