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Fig. 2 | Genes and Environment

Fig. 2

From: Progerin, the protein responsible for the Hutchinson-Gilford progeria syndrome, increases the unrepaired DNA damages following exposure to ionizing radiation

Fig. 2

The number of unrepairable DSB foci in relation to dysmorphic nuclear shape. a, b Number of unrepairable 53BP1 foci in dysmorphic (ESR ≥1.05) and normal (ESR ≤1.015) nuclei in the 6-Gy/1-month cell population. c Improvement of nuclear shapes by FTI treatment (25 μM) in HGPS cells. d Nuclear shapes (upper panels) and Western blot of lamin A/C and progerin expression (lower panels) after the FTI treatment. The band which appeared above the lamin A band indicates unprocessed prelamin A peptides (lower panel, right lane). e Reduction in the number of unrepairable DSB foci by pretreatment of HGPS cells with FTI (results of 6 Gy exposure and 1 week incubation). f HeLa S3 nuclei expressing GFP-progerin (left panel). DAPI staining of mock transfected HeLa nuclei (right panel)

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