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Fig. 5 | Genes and Environment

Fig. 5

From: Progerin, the protein responsible for the Hutchinson-Gilford progeria syndrome, increases the unrepaired DNA damages following exposure to ionizing radiation

Fig. 5

Cell aging and nuclear lamins. a Western analyses of lamin isoforms in different cells. ES, embryonic stem cells (ES-R1); MEF, mouse embryonic fibroblasts; Y (young) and S (senescent) MJ90 cells; HGPS cells (AG11513) and its immortalized line by hTERT, HGPS(Tert). b Western analysis of progerin. P, parental; T, hTERT immortalized cells. c Irradiation-associated aging causes decreased expression of lamin B1 in early passages of MJ90 cells. Lane C represents untreated cells, and lanes 1 and 2 represent 12 Gy-irradiated cells with post-irradiation incubation of 1 day or 3 months, respectively. d Ratio of lamin A/lamin B1 in cells at various conditions; see legend to Fig. 5a

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Genes and Environment

ISSN: 1880-7062

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