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Table 3 Protein products of OGG1 isoforms according to NCBI

From: An active alternative splicing isoform of human mitochondrial 8-oxoguanine DNA glycosylase (OGG1)

Type Name Protein accession Amino acids From exon 1 From exon 2 From exon 3 From exon 4 From exon 5 From exon 6 From exon 7 From exon 8 Identical to OGG1-1a Identical to OGG1-2a MTS NLS OGG1 activity
1 OGG1-1a NP_002533 345 46a 83a 60a 60 51a 16 29 No 1-316 9 to 26 335-341 Active [6]
1 OGG1-1b NP_058212 324 46a 83a 60a 60 51a 24 No No 1-317 1-316 9 to 26 No Active [11]
1 OGG1-1c NP_058213 410 46a 83a 60a 60 51a 16 94 No 1-316 1-316 9 to 26 No ND
2 OGG1-2a NP_058214 424 46a 83a 60a 60 51a 16 No 108a 1-316 9 to 26 No Unresolved [9, 10]
2 OGG1-2b NP_058434 357 46a 83a 60a 60 No No No 108a 1-249 1-249, 250–357 -2b: 317–424 -2a 9 to 26 No ND
2 OGG1-2c NP_058436 195 46a 83a 60a No No No No 6b 1-190 1-190 9 to 26 No ND
2 OGG1-2d NP_058437 356 46a 83a 60a 60 51a 16 34a 6b 1-316 1-316 9 to 26 No ND
2 OGG1-2e NP_058438 322 46a 83a 60a 60 51a 16 6 No 1-316 1-316 9 to 26 No ND
  1. Bold columns show differences among isoforms
  2. Abbreviations: MTS mitochondrial localization signal, RRMGHRTLASTPALWASI, NLS nuclear localization signal, KRRKGSK., ND not determined
  3. a indicates amino acids encoded cross a splice junction. b the same amino acid sequence. c the same amino aid sequence