An active alternative splicing isoform of human mitochondrial 8-oxoguanine DNA glycosylase (OGG1)

Genes and Environment

Table 3 Protein products of OGG1 isoforms according to NCBI

Type	Name	Protein accession	Amino acids	From exon 1	From exon 2	From exon 3	From exon 4	From exon 5	From exon 6	From exon 7	From exon 8	Identical to OGG1-1a	Identical to OGG1-2a	MTS	NLS	OGG1 activity
1	OGG1-1a	NP_002533	345	46^a	83^a	60^a	60	51^a	16	29	No	—	1-316	9 to 26	335-341	Active [6]
1	OGG1-1b	NP_058212	324	46^a	83^a	60^a	60	51^a	24	No	No	1-317	1-316	9 to 26	No	Active [11]
1	OGG1-1c	NP_058213	410	46^a	83^a	60^a	60	51^a	16	94	No	1-316	1-316	9 to 26	No	ND
2	OGG1-2a	NP_058214	424	46^a	83^a	60^a	60	51^a	16	No	108^a	1-316	—	9 to 26	No	Unresolved [9, 10]
2	OGG1-2b	NP_058434	357	46^a	83^a	60^a	60	No	No	No	108^a	1-249	1-249, 250–357 -2b: 317–424 -2a	9 to 26	No	ND
2	OGG1-2c	NP_058436	195	46^a	83^a	60^a	No	No	No	No	6^b	1-190	1-190	9 to 26	No	ND
2	OGG1-2d	NP_058437	356	46^a	83^a	60^a	60	51^a	16	34^a	6^b	1-316	1-316	9 to 26	No	ND
2	OGG1-2e	NP_058438	322	46^a	83^a	60^a	60	51^a	16	6	No	1-316	1-316	9 to 26	No	ND

Bold columns show differences among isoforms
Abbreviations: MTS mitochondrial localization signal, RRMGHRTLASTPALWASI, NLS nuclear localization signal, KRRKGSK., ND not determined
^a indicates amino acids encoded cross a splice junction. ^b the same amino acid sequence. ^c the same amino aid sequence

ISSN: 1880-7062