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Fig. 2 | Genes and Environment

Fig. 2

From: Collaborative studies in toxicogenomics in rodent liver in JEMS·MMS; a useful application of principal component analysis on toxicogenomics

Fig. 2

Principal component analysis (PCA) of the gene expression levels between genotoxic and non-genotoxic hepatocarcinogens in mouse liver as quantified by qPCR. The mean values of triplicate qPCR assays for each sample were analyzed statistically using the PCA program in GeneSpringGX11.0.1. The results of the PCA are shown as the two-dimensional contribution scores for component numbers 1 and 2 (PC1 and PC2). The contribution scores were produced by conversion from each eigenvector value, at 4 h with 7 genes (a) and at 48 h (b) and a combination of both time points (c) with 12 genes described in the text. Genotoxic hepatocarcinogens, red colored, DIPN: diisopropanolnitrosamine, NNK: 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, NNM: N-nitrosomorpholine, QN: quinoline, DAT: 2,4-diaminotoluene, DAB: 4-domethylaninoazobenzene, 2AAF: 2-acetylaminofluorene, URE: urethane) and non-genotoxic hepatocarcinogens (blue-colored, FUR: furan, DDT: dichlorodiphenyltrichloroethane, DEHP: di(2-ethylhezyl)phthalate, DCB: 1,4-dichlorobenzene). Dashed line is added between genotoxic and non-genotoxic hepatocarcinogens. Fig. 2 in [13]

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