Skip to main content

Advertisement

Table 3 Effect of HCAs in colon carcinogenesis in case control studiesa

From: Cancer in Japan: Prevalence, prevention and the role of heterocyclic amines in human carcinogenesis

Author (ref) Country/year No. case/control HCA OR P-trend
Budhathoki S et al. [12] Japan, 2015 738/697 MeIQ 2.80 (qu)b 0.005c
    HCA 1.73 0.03c
Fu Z et al. [16] USA, 2011 2,543/3764 PhIP 1.3 (qu) 0.005
    MeIQx 1.4 0.062
Helmus DS et al. [17] USA, 2013 1062/1645 MeIQx 1.73 (qu) <0.0001
    DiMeIQx 1.88 <0.0001
    red meat PhIP 1.38 0.009
    white meat PhIP 0.86 0.180
Barbir A et al. [18] Switzerland, 2012 413/796 PhIP 1.75 (qi) 0.006
    MeIQx 1.57 0.022
    DiMeIQx 1.46 0.045
Gilsing AM et al. [19] USA, 2012 1243/1419 MeQx 1.43 (t) 0.007
    MeIQx-NAT1   0.001d
  1. aDetection of adenoma by colonoscopy, b qu quartiles, qi quintiles
  2. cFor women but not for men, dInteraction with NAT1