Fig. 1From: Mutations induced by 8-hydroxyguanine (8-oxo-7,8-dihydroguanine), a representative oxidized base, in mammalian cellsMutation induction by dATP incorporation opposite GO in template DNA. When the syn-oriented GO base forms a Hoogsteen-type base pair with the A base of dATP in the active site of a DNA polymerase, this pairing causes the G➔T mutations. represents a phosphate groupBack to article page