Mutations induced by 8-hydroxyguanine (8-oxo-7,8-dihydroguanine), a representative oxidized base, in mammalian cells

Table 1 Expected functions of cellular proteins related to mutations by G^O directly produced in DNA

Protein		Role
Specialized DNA pol
	pol η	error-free bypass
	pol ζ	error-free bypass
	pol κ	error-prone bypass
	pol λ	error-free bypass, suppression of untargeted mutations
DNA glycosylase
	OGG1	suppression of G→T mutation by G^O removal
	MUTYH	suppression of G→T mutation by A removal
	NTH1	suppression of G→T mutation
	NEIL1	suppression of G→T mutation
WRN		suppression of untargeted mutations

ISSN: 1880-7062