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Table 1 Expected functions of cellular proteins related to mutations by GO directly produced in DNA

From: Mutations induced by 8-hydroxyguanine (8-oxo-7,8-dihydroguanine), a representative oxidized base, in mammalian cells

Protein   Role
Specialized DNA pol   
  pol η error-free bypass
  pol ζ error-free bypass
  pol κ error-prone bypass
  pol λ error-free bypass, suppression of untargeted mutations
DNA glycosylase   
  OGG1 suppression of G→T mutation by GO removal
  MUTYH suppression of G→T mutation by A removal
  NTH1 suppression of G→T mutation
  NEIL1 suppression of G→T mutation
WRN   suppression of untargeted mutations