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Table 2 Expected functions of cellular proteins related to dGOTP-induced mutation

From: Mutations induced by 8-hydroxyguanine (8-oxo-7,8-dihydroguanine), a representative oxidized base, in mammalian cells

Protein   Role
Specialized DNA pol   
  pol η incorporation of dGOTP
  pol ζ incorporation of dGOTP
  REV1 incorporation of dGOTP
DNA glycosylase   
  MUTYH promotion of A:T→C:G mutation
Nucleotide pool sanitization enzyme   
  MTH1 decrease of dGOTP
  MTH2 decrease of dGOTP
  NUDT5 decrease of dGOTP