Mutations induced by 8-hydroxyguanine (8-oxo-7,8-dihydroguanine), a representative oxidized base, in mammalian cells

Table 2 Expected functions of cellular proteins related to dG^OTP-induced mutation

Protein		Role
Specialized DNA pol
	pol η	incorporation of dG^OTP
	pol ζ	incorporation of dG^OTP
	REV1	incorporation of dG^OTP
DNA glycosylase
	MUTYH	promotion of A:T→C:G mutation
Nucleotide pool sanitization enzyme
	MTH1	decrease of dG^OTP
	MTH2	decrease of dG^OTP
	NUDT5	decrease of dG^OTP

ISSN: 1880-7062