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Table 3 Establishment of umu tester strains overexpressing bacterial and mammalian metabolic enzymes

From: Development and progress for three decades in umu test systems

S. typhimurium Character Detection Reference
NM1011 Nitroreductase-overexpressing Nitroarenes [7, 34]
NM2009 O-AT-overexpressing Arylamines [7, 35, 36]
NM3009 Nitroreductase- and O-AT-overexpressing Nitroarenes, Arylamines [7, 35, 70, 71]
OY1002/1A1 Human P4501A1 and NPR, and O-AT overexpressing PAH, Arylamines [8, 70]
OY1002/1A2 Human P4501A2 and NPR, and O-AT overexpressing Arylamines [8, 51, 70]
OY1002/1B1 Human P4501B1 and NPR, and O-AT overexpressing PAH, Arylamines [8, 70]
OY1002/2C9 Human P4502C9 and NPR, and O-AT overexpressing   [8, 70]
OY1002/2D6 Human P4502D6 and NPR, and O-AT expressing   [8, 70]
OY1002/2E1 Human P4502E1 and NPR, and O-AT overexpressing Nitrosoamines [8, 70]
OY1002/3A4 Human P4503A4 and NPR, and O-AT overexpressing Aflatoxins [8, 70]
NM6001 Human N-acetyltransferase 1 overexpressing Arylamines, Nitroarenes [10, 67, 73]
NM6002 Human N-acetyltransferase 2 overexpressing Arylamines, Nitroarenes [10, 67, 73]
NM7001 Human sulfotransferase 1A1 overexpressing Arylamines Benzylic alcohols [11]
NM7002 Human sulfotransferase 1A2 overexpressing Arylamines [11]
NM7003 Human sulfotransferase 1A3 overexpressing Alkenylbenzenes [11]
NM5004 Rat glutathione S-transferase Overexpressing Dihaloalkenes [9, 60]
  1. NPR, NADPH-P450 reductase; O-AT, O-acetyltransferase; PAH, polycyclic aromatic hydrocarbon