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Table 3 Establishment of umu tester strains overexpressing bacterial and mammalian metabolic enzymes

From: Development and progress for three decades in umu test systems

S. typhimurium

Character

Detection

Reference

NM1011

Nitroreductase-overexpressing

Nitroarenes

[7, 34]

NM2009

O-AT-overexpressing

Arylamines

[7, 35, 36]

NM3009

Nitroreductase- and O-AT-overexpressing

Nitroarenes, Arylamines

[7, 35, 70, 71]

OY1002/1A1

Human P4501A1 and NPR, and O-AT overexpressing

PAH, Arylamines

[8, 70]

OY1002/1A2

Human P4501A2 and NPR, and O-AT overexpressing

Arylamines

[8, 51, 70]

OY1002/1B1

Human P4501B1 and NPR, and O-AT overexpressing

PAH, Arylamines

[8, 70]

OY1002/2C9

Human P4502C9 and NPR, and O-AT overexpressing

 

[8, 70]

OY1002/2D6

Human P4502D6 and NPR, and O-AT expressing

 

[8, 70]

OY1002/2E1

Human P4502E1 and NPR, and O-AT overexpressing

Nitrosoamines

[8, 70]

OY1002/3A4

Human P4503A4 and NPR, and O-AT overexpressing

Aflatoxins

[8, 70]

NM6001

Human N-acetyltransferase 1 overexpressing

Arylamines, Nitroarenes

[10, 67, 73]

NM6002

Human N-acetyltransferase 2 overexpressing

Arylamines, Nitroarenes

[10, 67, 73]

NM7001

Human sulfotransferase 1A1 overexpressing

Arylamines Benzylic alcohols

[11]

NM7002

Human sulfotransferase 1A2 overexpressing

Arylamines

[11]

NM7003

Human sulfotransferase 1A3 overexpressing

Alkenylbenzenes

[11]

NM5004

Rat glutathione S-transferase Overexpressing

Dihaloalkenes

[9, 60]

  1. NPR, NADPH-P450 reductase; O-AT, O-acetyltransferase; PAH, polycyclic aromatic hydrocarbon