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Table 6 Comparison of substrate specificity of human sulfotransferases expressed in S. typhimurium TA1538/1,8-DNP/pSK1002 towards a variety of chemicals [11]

From: Development and progress for three decades in umu test systems

Chemicals

S9

SULT isoforms

Arylamines

 2-Aminoanthracene

+

1A1 = 1A2

 2-Aminofluorene

+

1A2

 2-Acetylaminofluorene

+

1A1 < 1A2

 4-Aminobiphenyl

+

1A1 = 1A2

 6-Aminochrysene

+

SR

 Aminophenylnorharman

+

1A1 < 1A2

 AαC

+

1A3 = 1A2 < 1A1

 Glu-P-1

+

1A1

 IQ

+

SR

 MeAαC

+

1A2 < 1A1

 MeIQ

+

SR

 3-MeO-AAB

+

1A1 = 1A2

 β-Naphthylamine

+

1A3 < 1A2 = 1A1

 PhIP

+

1A1 < 1A2

 Trp-P-1

+

SR

 Trp-P-2

+

SR

Nitroarenes

 Furylfuramide

−

1A2

 5-Nitroacenaphthene

−

1A1

 3-Nitrobenzanthrone

−

1A2 < 1A1

 2-Nitrofluorene

−

1A2

 Nitrofurazone

−

SR

 3-Nitrofluoranthene

−

1A1

 1-Nitronaphthalene

−

SR

 1-Nitropyrene

−

1A2

 2-Nitropropane

−

1A2

 4-Nitroquinoline 1-oxide

−

SR

 2-Nitrotriphenylene

−

SR

 4,4′-Dinitrobiphenyl

−

1A1 = 1A2

 3,7-Dinitrofluoranthene

−

1A2 < 1A1

 3,9-Dinitrofluoranthene

−

1A2 < 1A1

 1,6-Dinitropyrene

−

SR

Benzylic and allylic alcohols

 Estragole

+

1A3

 Hycanthone

−

1A1 = 1A3

 1′-Hydoxysafrole

−

1A3

 1-Hydroxymethylpyrene

−

1A3 < 1A2 < 1A1

  1. SR presents same response in all strains
  2. AαC, 2-amino-9H-pyrido[2,3-b]indole; Glu-P-1, 2-amino-6-methyl-dipyrido[1,2-α:3′,2′-d]imidazole; IQ, 2-amino-3-methylimidazo[4,5-f]quinoline; MeAαC, 2-amino-3-methyl9H-pyrido[2,3-b]indole; MeIQ, 2-amino-3,5-dimethylimidazo[4,5-f]quinoline; 3-MeO-AAB, 3-methoxy-4-aminoazobenzene; PhIP, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine; Trp-P-1, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole; Trp-P-2, 3-amino-1-methyl-5H-pyrido[4,3-b]indole