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Table 6 Comparison of substrate specificity of human sulfotransferases expressed in S. typhimurium TA1538/1,8-DNP/pSK1002 towards a variety of chemicals [11]

From: Development and progress for three decades in umu test systems

Chemicals S9 SULT isoforms
Arylamines
 2-Aminoanthracene + 1A1 = 1A2
 2-Aminofluorene + 1A2
 2-Acetylaminofluorene + 1A1 < 1A2
 4-Aminobiphenyl + 1A1 = 1A2
 6-Aminochrysene + SR
 Aminophenylnorharman + 1A1 < 1A2
 AαC + 1A3 = 1A2 < 1A1
 Glu-P-1 + 1A1
 IQ + SR
 MeAαC + 1A2 < 1A1
 MeIQ + SR
 3-MeO-AAB + 1A1 = 1A2
 β-Naphthylamine + 1A3 < 1A2 = 1A1
 PhIP + 1A1 < 1A2
 Trp-P-1 + SR
 Trp-P-2 + SR
Nitroarenes
 Furylfuramide 1A2
 5-Nitroacenaphthene 1A1
 3-Nitrobenzanthrone 1A2 < 1A1
 2-Nitrofluorene 1A2
 Nitrofurazone SR
 3-Nitrofluoranthene 1A1
 1-Nitronaphthalene SR
 1-Nitropyrene 1A2
 2-Nitropropane 1A2
 4-Nitroquinoline 1-oxide SR
 2-Nitrotriphenylene SR
 4,4′-Dinitrobiphenyl 1A1 = 1A2
 3,7-Dinitrofluoranthene 1A2 < 1A1
 3,9-Dinitrofluoranthene 1A2 < 1A1
 1,6-Dinitropyrene SR
Benzylic and allylic alcohols
 Estragole + 1A3
 Hycanthone 1A1 = 1A3
 1′-Hydoxysafrole 1A3
 1-Hydroxymethylpyrene 1A3 < 1A2 < 1A1
  1. SR presents same response in all strains
  2. AαC, 2-amino-9H-pyrido[2,3-b]indole; Glu-P-1, 2-amino-6-methyl-dipyrido[1,2-α:3′,2′-d]imidazole; IQ, 2-amino-3-methylimidazo[4,5-f]quinoline; MeAαC, 2-amino-3-methyl9H-pyrido[2,3-b]indole; MeIQ, 2-amino-3,5-dimethylimidazo[4,5-f]quinoline; 3-MeO-AAB, 3-methoxy-4-aminoazobenzene; PhIP, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine; Trp-P-1, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole; Trp-P-2, 3-amino-1-methyl-5H-pyrido[4,3-b]indole