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Table 2 Harmonic means of TD50 values and total dose/IMF (T/I; potency of in vivo mutagenicity) values of genotoxic carcinogens in mouse liver and lung

From: Evaluation of in vivo mutagenesis for assessing the health risk of air pollutants

Tissues

Compounds (administration method)

Harmonic mean of TD50 (mg/kg/day)

Harmonic mean of T/I (mg/kg)

Liver

2-acetylaminofluorene (diet)

7.81

231

4-aminodiphenyl (diet)

1.58

15.3

4-chloro-o-phenylenediamine (diet)

1341

7623

2,4-diaminotoluene (diet)

26.7

1688

dichloroacetic acid (diet)

155

66867

MeIQ (diet)

27.1

272

MeIQx (diet)

24.3

104

N-nitrosodimethylamine (gavage)

0.253

0.69

urethane (diet)

39

427

Lung

benzene (inhalation)

175

4937

1,3-butadiene (inhalation)

41.8

532

cyclophosphamide (ip injection)

5.92

16.6

ethylene oxide (inhalation)

63.4

897

urethane (diet)

28.3

303

  1. The data for calculating these values are listed in Additional file 1