From: Evaluation of in vivo mutagenesis for assessing the health risk of air pollutants
Tissues | Compounds (administration method) | Harmonic mean of TD50 (mg/kg/day) | Harmonic mean of T/I (mg/kg) |
---|---|---|---|
Liver | 2-acetylaminofluorene (diet) | 7.81 | 231 |
4-aminodiphenyl (diet) | 1.58 | 15.3 | |
4-chloro-o-phenylenediamine (diet) | 1341 | 7623 | |
2,4-diaminotoluene (diet) | 26.7 | 1688 | |
dichloroacetic acid (diet) | 155 | 66867 | |
MeIQ (diet) | 27.1 | 272 | |
MeIQx (diet) | 24.3 | 104 | |
N-nitrosodimethylamine (gavage) | 0.253 | 0.69 | |
urethane (diet) | 39 | 427 | |
Lung | benzene (inhalation) | 175 | 4937 |
1,3-butadiene (inhalation) | 41.8 | 532 | |
cyclophosphamide (ip injection) | 5.92 | 16.6 | |
ethylene oxide (inhalation) | 63.4 | 897 | |
urethane (diet) | 28.3 | 303 |