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Table 2 Harmonic means of TD50 values and total dose/IMF (T/I; potency of in vivo mutagenicity) values of genotoxic carcinogens in mouse liver and lung

From: Evaluation of in vivo mutagenesis for assessing the health risk of air pollutants

Tissues Compounds (administration method) Harmonic mean of TD50 (mg/kg/day) Harmonic mean of T/I (mg/kg)
Liver 2-acetylaminofluorene (diet) 7.81 231
4-aminodiphenyl (diet) 1.58 15.3
4-chloro-o-phenylenediamine (diet) 1341 7623
2,4-diaminotoluene (diet) 26.7 1688
dichloroacetic acid (diet) 155 66867
MeIQ (diet) 27.1 272
MeIQx (diet) 24.3 104
N-nitrosodimethylamine (gavage) 0.253 0.69
urethane (diet) 39 427
Lung benzene (inhalation) 175 4937
1,3-butadiene (inhalation) 41.8 532
cyclophosphamide (ip injection) 5.92 16.6
ethylene oxide (inhalation) 63.4 897
urethane (diet) 28.3 303
  1. The data for calculating these values are listed in Additional file 1