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Fig. 5 | Genes and Environment

Fig. 5

From: DNA polymerase kappa protects human cells against MMC-induced genotoxicity through error-free translesion DNA synthesis

Fig. 5

A schematic of the role of Pol κ in MMC-induced inter-strand crosslinks repair. When wild-type Pol κ is functional, error-free TLS suppresses mutation inductions (left). When Pol κ is deficient, other TLS Pols, such as Pol ζ, bypass the lesions in an error-prone manner (middle), or replication stalling leads to chromosomal alteration or cell death (right)

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Genes and Environment

ISSN: 1880-7062

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