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Table 1 Baseline frequencies of the TK −/− mutation, CA and SCE in Nalm-6-MSH+ TK+/- cells and their Pol κ derivatives

From: DNA polymerase kappa protects human cells against MMC-induced genotoxicity through error-free translesion DNA synthesis

 

TK mutant frequencya

CAb

SCEc

 

(×10−6)

(%)

(incidence/cell)

WT TK+/-

7.8 ± 2.4

1.5

4.5 ± 2.2

KO TK+/-

14.1 ± 2.9

2.0

6.9 ± 2.9*

CD TK+/-

9.9 ± 3.2

1.0

4.9 ± 1.8

  1. aValues are the mean ± S.E. (n = 3)
  2. bTwo hundred metaphase cells were analyzed for each cell type (n = 1)
  3. cFifty metaphase cells were analyzed. Data are expressed as the mean ± S.D. (n = 1). * denotes a significant difference compared to WT TK+/- cells
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Genes and Environment

ISSN: 1880-7062

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