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Table 1 Baseline frequencies of the TK −/− mutation, CA and SCE in Nalm-6-MSH+ TK+/- cells and their Pol κ derivatives

From: DNA polymerase kappa protects human cells against MMC-induced genotoxicity through error-free translesion DNA synthesis

  TK mutant frequencya CAb SCEc
  (×10−6) (%) (incidence/cell)
WT TK+/- 7.8 ± 2.4 1.5 4.5 ± 2.2
KO TK+/- 14.1 ± 2.9 2.0 6.9 ± 2.9*
CD TK+/- 9.9 ± 3.2 1.0 4.9 ± 1.8
  1. aValues are the mean ± S.E. (n = 3)
  2. bTwo hundred metaphase cells were analyzed for each cell type (n = 1)
  3. cFifty metaphase cells were analyzed. Data are expressed as the mean ± S.D. (n = 1). * denotes a significant difference compared to WT TK+/- cells
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Genes and Environment

ISSN: 1880-7062

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