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Table 2 Summary of transgenic rat models for carcinogenesis

From: Transgenic rat models for mutagenesis and carcinogenesis

Appellation Transgene Feature Target organ Usage Reference
Hras128 carrying three copies of the human c-Ha-ras proto-oncogene, including its own promoter region Highly susceptible to chemical-induced carcinogenesis mammary gland, esophagus,bladder carcinogenesis mechanisms, screening for chemo preventive agents [138]
TRAP the simian virus 40 (SV40) large T antigen under probasin promoter control Males demonstrate atypical epithelial cell proliferation in the prostate from 4 weeks of age and develop prostate carcinomas at 100 % incidence before they are 15 weeks old prostate carcinogenesis mechanisms, screening for chemo preventive agents [145]
Cx32Δ Tg a dominant negative mutant of the connexin 32 gene under albumin promoter control The gap junctional intercellular communications were disrupted in the liver and highly susceptible to chemical-induced hepatocarcinogenesis. liver carcinogenesis mechanisms [150]
alb-SV40 Tag Transgenic Rat promoter-enhancer sequences of the mouse albumine gene linked 5' to the simian virus-40 T antigen gene All animal exhibit focal lesions and nodules in liver at 4 months of age. These lesions were GST-P negative. liver mechanism study of spontaneous hepatocarcinogenesis in this transgenic rats [198]
Hras250 human Ha-ras G12V oncogene regulated by the Cre/lox system targeted activation of a human oncogenic-ras transgene in rat pancreas induce pancreatic ductal adenocarcinomas Pancreas carcinogenesis mechanisms [153]
Kras327 human K-rasG12V oncogene regulated by the Cre/lox system targeted activation of a human oncogenic-ras transgene in rat pancreas induce pancreatic ductal adenocarcinomas Pancreas carcinogenesis mechanisms [152]