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Table 2 Summary of transgenic rat models for carcinogenesis

From: Transgenic rat models for mutagenesis and carcinogenesis

Appellation

Transgene

Feature

Target organ

Usage

Reference

Hras128

carrying three copies of the human c-Ha-ras proto-oncogene, including its own promoter region

Highly susceptible to chemical-induced carcinogenesis

mammary gland, esophagus,bladder

carcinogenesis mechanisms, screening for chemo preventive agents

[138]

TRAP

the simian virus 40 (SV40) large T antigen under probasin promoter control

Males demonstrate atypical epithelial cell proliferation in the prostate from 4 weeks of age and develop prostate carcinomas at 100 % incidence before they are 15 weeks old

prostate

carcinogenesis mechanisms, screening for chemo preventive agents

[145]

Cx32Δ Tg

a dominant negative mutant of the connexin 32 gene under albumin promoter control

The gap junctional intercellular communications were disrupted in the liver and highly susceptible to chemical-induced hepatocarcinogenesis.

liver

carcinogenesis mechanisms

[150]

alb-SV40 Tag Transgenic Rat

promoter-enhancer sequences of the mouse albumine gene linked 5' to the simian virus-40 T antigen gene

All animal exhibit focal lesions and nodules in liver at 4 months of age. These lesions were GST-P negative.

liver

mechanism study of spontaneous hepatocarcinogenesis in this transgenic rats

[198]

Hras250

human Ha-ras G12V oncogene regulated by the Cre/lox system

targeted activation of a human oncogenic-ras transgene in rat pancreas induce pancreatic ductal adenocarcinomas

Pancreas

carcinogenesis mechanisms

[153]

Kras327

human K-rasG12V oncogene regulated by the Cre/lox system

targeted activation of a human oncogenic-ras transgene in rat pancreas induce pancreatic ductal adenocarcinomas

Pancreas

carcinogenesis mechanisms

[152]