From: Transgenic rat models for mutagenesis and carcinogenesis
Appellation | Transgene | Feature | Target organ | Usage | Reference |
---|---|---|---|---|---|
Hras128 | carrying three copies of the human c-Ha-ras proto-oncogene, including its own promoter region | Highly susceptible to chemical-induced carcinogenesis | mammary gland, esophagus,bladder | carcinogenesis mechanisms, screening for chemo preventive agents | [138] |
TRAP | the simian virus 40 (SV40) large T antigen under probasin promoter control | Males demonstrate atypical epithelial cell proliferation in the prostate from 4Â weeks of age and develop prostate carcinomas at 100Â % incidence before they are 15Â weeks old | prostate | carcinogenesis mechanisms, screening for chemo preventive agents | [145] |
Cx32Δ Tg | a dominant negative mutant of the connexin 32 gene under albumin promoter control | The gap junctional intercellular communications were disrupted in the liver and highly susceptible to chemical-induced hepatocarcinogenesis. | liver | carcinogenesis mechanisms | [150] |
alb-SV40 Tag Transgenic Rat | promoter-enhancer sequences of the mouse albumine gene linked 5' to the simian virus-40Â T antigen gene | All animal exhibit focal lesions and nodules in liver at 4Â months of age. These lesions were GST-P negative. | liver | mechanism study of spontaneous hepatocarcinogenesis in this transgenic rats | [198] |
Hras250 | human Ha-ras G12V oncogene regulated by the Cre/lox system | targeted activation of a human oncogenic-ras transgene in rat pancreas induce pancreatic ductal adenocarcinomas | Pancreas | carcinogenesis mechanisms | [153] |
Kras327 | human K-rasG12V oncogene regulated by the Cre/lox system | targeted activation of a human oncogenic-ras transgene in rat pancreas induce pancreatic ductal adenocarcinomas | Pancreas | carcinogenesis mechanisms | [152] |