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Fig. 3 | Genes and Environment

Fig. 3

From: Modulation of benzo[a]pyrene–DNA adduct formation by CYP1 inducer and inhibitor

Fig. 3

Scheme of the relationship between AhR modulators and BaP–DNA adduct formation. Broken arrows indicate the pathway of BaP metabolism. Solid arrows indicate the activation or inductive commitment, whereas the T-shaped lines indicate inhibition. The “protective pathway” and “aggravating pathway” are indicated in blue and red, respectively. AhR modulators influence BaP adducts through CYP1A1/1B1 gene induction (a), reduction (b), and/or inhibition of enzyme activity (c). Note that only CYP1A1 has a BPDE metabolic detoxification indicated by a blue arrow

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