Fig. 3From: Modulation of benzo[a]pyrene–DNA adduct formation by CYP1 inducer and inhibitorScheme of the relationship between AhR modulators and BaP–DNA adduct formation. Broken arrows indicate the pathway of BaP metabolism. Solid arrows indicate the activation or inductive commitment, whereas the T-shaped lines indicate inhibition. The “protective pathway” and “aggravating pathway” are indicated in blue and red, respectively. AhR modulators influence BaP adducts through CYP1A1/1B1 gene induction (a), reduction (b), and/or inhibition of enzyme activity (c). Note that only CYP1A1 has a BPDE metabolic detoxification indicated by a blue arrow Back to article page