Fig. 1
From: Giemsa-stained pseudo-micronuclei in rat skin treated with vitamin D3 analog, pefcalcitol
Results of the CA test of pefcalcitol in CHL cells. Percentage of structural chromosomal aberrations (CA%) did not increase with the treatment of pefcalcitol under any treatment conditions: 24-h treatment without S9 derived from rat liver (a), 6-h treatment without S9 (b), and 6-h treatment with S9 (c). Percentages of relative cell counts (RCC%) to vehicle control decreased in a dose-dependent manner, which indicated sufficient exposure of the test chemical