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Table 1 Genotype distribution, allele frequencies and association analysis of the rs3892097 (G/A) polymorphism in Pakistani population

From: Further evidence for the association of CYP2D6*4 gene polymorphism with Parkinson’s disease: a case control study

Genotype distribution
  GG GA AA Total HWE (p-value)
PD 145 (83.3%) 21 (12.0%) 8 (4.5%) 174 0.89
Control 182 (91.0%) 18 (9.0%) 0 (0%) 200 0.95
Total 327 39 8 374 0.92
Allelic distribution
  G A Total
PD 311 (89.3%) 37 (10.6%) 348
Control 382 (95.5%) 18 (4.4%) 400
Total 694 55 748
Genetic model and statistical data
Genetic model Odds ratio (95% CI) Chi-square Degrees of freedom P
Allele contrast
(G vs. A)
2.52 (1.40-4.52) 10.27 1 0.001
Dominant
(GA + AA vs. GG)
2.02 (1.07-3.78) 4.97 1 0.02
Recessive
(AA vs GG + GA)
Infinitea 9.23 1 0.002
  1. aThe OR and 95% CI of the recessive model could not be calculated since there was no homozygous CYP2D6*4 observed in the control group