Table 1 Genotype distribution, allele frequencies and association analysis of the rs3892097 (G/A) polymorphism in Pakistani population
Genotype distribution | |||||
GG | GA | AA | Total | HWE (p-value) | |
PD | 145 (83.3%) | 21 (12.0%) | 8 (4.5%) | 174 | 0.89 |
Control | 182 (91.0%) | 18 (9.0%) | 0 (0%) | 200 | 0.95 |
Total | 327 | 39 | 8 | 374 | 0.92 |
Allelic distribution | |||||
G | A | Total | |||
PD | 311 (89.3%) | 37 (10.6%) | 348 | ||
Control | 382 (95.5%) | 18 (4.4%) | 400 | ||
Total | 694 | 55 | 748 | ||
Genetic model and statistical data | |||||
Genetic model | Odds ratio (95% CI) | Chi-square | Degrees of freedom | P | |
Allele contrast (G vs. A) | 2.52 (1.40-4.52) | 10.27 | 1 | 0.001 | |
Dominant (GA + AA vs. GG) | 2.02 (1.07-3.78) | 4.97 | 1 | 0.02 | |
Recessive (AA vs GG + GA) | Infinitea | 9.23 | 1 | 0.002 | |