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Fig. 6 | Genes and Environment

Fig. 6

From: Unique molecular mechanisms for maintenance and alteration of genetic information in the budding yeast Saccharomyces cerevisiae

Fig. 6

Regulation of HR by factors in Rad52 epistasis group. Upon formation of a DSB, the 3′ single-stranded DNA (ssDNA) end is created by resection. The ssDNA tails are coated by RPA to eliminate secondary structures [62, 63]. Rad52p that possesses multifunctions including the binding activity to both Rad51p and RPA mediates recombination by recruiting Rad51p to RPA-ssDNA complex [64, 65]. Rad52p displaces RPA to enable formation of Rad51p filament extending on the ssDNA, along with Rad55p-Rad57p heterodimer [66,67,68,69,70]. Subsequent genome-wide search for homologous sequences and DNA strand exchange with D-loop formation are accomplished by Rad51p-Rad54p interaction [71,72,73,74,75,76]. At the end of these processes, Rad54p catalyzes the removal of Rad51p from dsDNA to provide DNA polymerases access for initiation of the repair DNA synthesis reaction

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Genes and Environment

ISSN: 1880-7062

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