Fig. 8

Molecular mechanism of the suppression of the cox15-TAA mutation by SUP7- o. In a cell containing wild-type SUP7, ribosome ceases translation elongation when it reaches the in-frame ochre mutation to produce a C-terminal truncated non-functional polypeptide (left). When an anticodon mutation occurs in the SUP7 gene, the ochre suppressor SUP7- o inserts tyrosine to suppress the ochre codon, and enables translation elongation to proceed in order to produce a full-length polypeptide (right)