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Table 3 Mutagenicity of MMC in urate-null mutants and wild-type flies

From: Increase of somatic cell mutations in oxidative damage-sensitive drosophila

Dose (mM) Survival (%) No. of wings No. of spots (spots/wing)
Small Large Total
y v ma-l; mwh × Oregon-R F1 females (uric acid +)
 0 100 161 17 (0.11) 3 (0.02) 20 (0.12)
 0.05 87 151 866 (5,74)** 349 (2.31)** 1215 (8.05)**
 0.1 105 181 1816 (10.0)** 611 (3.38)** 2427 (13.4)**
y v ma-l; mwh × y v ma-l F1 females (uric acid -)
 0 100 113 65 (0.58) 10 (0.09) 75 (0.66)
 0.05 44 50 769 (15.4)** 298 (5.96)* 1067 (21.3)**
 0.1 56 64 2038 (31.8)** 488 (7.63)** 2529 (39.5)**
  1. *P ≤ 0.05, **P ≤ 0.01, a significant increase in comparison to the corresponding control