Skip to main content

Table 4 Mutagenicity of 4NQO in urate-null mutants and wild-type flies

From: Increase of somatic cell mutations in oxidative damage-sensitive drosophila

Dose (mM) Survival (%) No. of wings No. of spot (spots/wing)
Small Large Total
y v ma-l; mwh × Oregon-R F1 females (uric acid +)
 0 100 100 10 (0.10) 3 (0.03) 13 (0.13)
 0.5 102 100 21 (0.21) 25 (0.25)* 46 (0.46)*
 1 96 100 42 (0.42)* 53 (0.53)* 95 (0.95)*
y v ma-l; mwh × y v ma-l F1 females (uric acid -)
 0 100 100 29 (0.29) 7 (0.07) 36 (0.36)
 0.5 94 100 86 (0.86)* 61 (0.61)* 147 (1.47)*
 1 61 100 108 (1.08)* 132 (1.32)* 240 (2.40)*
  1. *P ≤ 0.01, a significant increase in comparison to the corresponding control