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Table 4 Mutagenicity of 4NQO in urate-null mutants and wild-type flies

From: Increase of somatic cell mutations in oxidative damage-sensitive drosophila

Dose (mM)

Survival (%)

No. of wings

No. of spot (spots/wing)

Small

Large

Total

y v ma-l; mwh × Oregon-R F1 females (uric acid +)

 0

100

100

10 (0.10)

3 (0.03)

13 (0.13)

 0.5

102

100

21 (0.21)

25 (0.25)*

46 (0.46)*

 1

96

100

42 (0.42)*

53 (0.53)*

95 (0.95)*

y v ma-l; mwh × y v ma-l F1 females (uric acid -)

 0

100

100

29 (0.29)

7 (0.07)

36 (0.36)

 0.5

94

100

86 (0.86)*

61 (0.61)*

147 (1.47)*

 1

61

100

108 (1.08)*

132 (1.32)*

240 (2.40)*

  1. *P ≤ 0.01, a significant increase in comparison to the corresponding control