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Table 5 Mutagenicity of NDMA in urate-null mutants and wild-type flies

From: Increase of somatic cell mutations in oxidative damage-sensitive drosophila

Dose (mM) Survival (%) No. of wings No. of spots (spots/wing)
Small Large Total
Exp. 1
 y v ma-l; mwh × Oregon-R F1 females (uric acid +)
  0 100 161 17 (0.11) 3 (0.02) 20 (0.12)
  1 90 146 158 (1.08)* 79 (0.54)* 273 (1.62)*
  5 14 22 32 (1.45)* 6 (0.27)* 38 (1.73)*
 y v ma-l; mwh × y v ma-l F1 females (uric acid -)
  0 100 113 65 (0.58) 10 (0.09) 75 (0.66)
  1 74 81 347 (4.28)* 57 (0.43)* 404 (4.99)*
  5 10 10 58 (5.80)* 2 (0.20) 60 (6.00)*
Exp. 2
 y v ma-l; mwh × Oregon-R F1 females (uric acid +)
  0 100 140 17 (0.12) 2 (0.01) 19 (0.14)
  0.25 91 166 98 (0.59)* 43 (0.26)* 141 (0.85)*
  0.5 90 156 177 (1.13)* 71 (0.46)* 248 (1.59)*
  1 88 184 373 (2.03)* 149 (0.81)* 522 (2.84)*
 y v ma-l; mwh × y v ma-l F1 females (uric acid -)
  0 100 135 49 (0.36) 6 (0.04) 55 (0.41)
  0.25 93 135 165 (1.22)* 56 (0.41)* 221 (1.64)*
  0.5 98 143 340 (2.38)* 87 (0.61)* 427 (2.99)*
  1 69 94 466 (4.96)* 136 (1.45)* 602 (6.40)*
Exp. 3
 mwh, ry506 × ry+ F1 females (uric acid +)
  0 100 82 110 (1.34) 13 (0.16) 123 (1.50)
  0.5 89 85 298 (3.51)* 144 (1.69)* 442 (5.20)*
 mwh, ry506 × ry506 F1 females (uric acid -)
  0 100 90 123 (1.37) 15 (0.17) 138 (1.53)
  0.5 65 58 447 (7.71)* 137 (2.36)* 584 (10.1)*
  1. *P ≤ 0.01, a significant increase in comparison to the corresponding control