Increase of somatic cell mutations in oxidative damage-sensitive drosophila

Genes and Environment

Table 5 Mutagenicity of NDMA in urate-null mutants and wild-type flies

Dose (mM)	Survival (%)	No. of wings	No. of spots (spots/wing)
Dose (mM)	Survival (%)	No. of wings	Small	Large	Total
Exp. 1
y v ma-l; mwh × Oregon-R F1 females (uric acid +)
0	100	161	17 (0.11)	3 (0.02)	20 (0.12)
1	90	146	158 (1.08)^*	79 (0.54)^*	273 (1.62)^*
5	14	22	32 (1.45)^*	6 (0.27)^*	38 (1.73)^*
y v ma-l; mwh × y v ma-l F1 females (uric acid -)
0	100	113	65 (0.58)	10 (0.09)	75 (0.66)
1	74	81	347 (4.28)^*	57 (0.43)^*	404 (4.99)^*
5	10	10	58 (5.80)^*	2 (0.20)	60 (6.00)^*
Exp. 2
y v ma-l; mwh × Oregon-R F1 females (uric acid +)
0	100	140	17 (0.12)	2 (0.01)	19 (0.14)
0.25	91	166	98 (0.59)^*	43 (0.26)^*	141 (0.85)^*
0.5	90	156	177 (1.13)^*	71 (0.46)^*	248 (1.59)^*
1	88	184	373 (2.03)^*	149 (0.81)^*	522 (2.84)^*
y v ma-l; mwh × y v ma-l F1 females (uric acid -)
0	100	135	49 (0.36)	6 (0.04)	55 (0.41)
0.25	93	135	165 (1.22)^*	56 (0.41)^*	221 (1.64)^*
0.5	98	143	340 (2.38)^*	87 (0.61)^*	427 (2.99)^*
1	69	94	466 (4.96)^*	136 (1.45)^*	602 (6.40)^*
Exp. 3
mwh, ry⁵⁰⁶ × ry⁺ F1 females (uric acid +)
0	100	82	110 (1.34)	13 (0.16)	123 (1.50)
0.5	89	85	298 (3.51)^*	144 (1.69)^*	442 (5.20)^*
mwh, ry⁵⁰⁶ × ry⁵⁰⁶ F1 females (uric acid -)
0	100	90	123 (1.37)	15 (0.17)	138 (1.53)
0.5	65	58	447 (7.71)^*	137 (2.36)^*	584 (10.1)^*

ISSN: 1880-7062