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Table 6 Mutagenicity of NDEA in urate-null mutants and wild-type flies

From: Increase of somatic cell mutations in oxidative damage-sensitive drosophila

Dose (mM) Survival (%) No. of wings No. of spots (spots/wing)
Small Large Total
Exp. 1
 y v ma-l; mwh × Oregon-R F1 females (uric acid +)
  0 100 140 17 (0.12) 2 (0.01) 19 (0.14)
  1 92 164 29 (0.18) 6 (0.04) 35 (0.21)
  3 90 158 38 (0.24)* 11 (0.07) 49 (0.31)**
  5 66 114 41 (0.36)** 6 (0.05) 47 (0.41)**
 y v ma-l; mwh × y v ma-l F1 females (uric acid -)
  0 100 135 49 (0.36) 6 (0.04) 55 (0.41)
  1 120 169 111 (0.66)** 21 (0.12)* 132 (0.78)**
  3 76 108 74 (0.69)** 25 (0.23)** 99 (0.92)**
  5 30 44 57 (1.30)** 16 (0.36)** 73 (1.66)**
Exp. 2
 y v ma-l; mwh × Oregon-R F1 females (uric acid +)
  0 100 151 19 (0.13) 4 (0.03) 23 (0.15)
  1 85 132 43 (0.33)** 19 (0.14)** 62 (0.47)**
  3 72 103 43 (0.42)** 14 (0.14)** 57 (0.55)**
  5 52 79 18 (0.23) 4 (0.05) 22 (0.28)
 y v ma-l; mwh × y v ma-l F1 females (uric acid -)
  0 100 117 46 (0.39) 11 (0.09) 57 (0.49)
  1 113 136 123 (0.90)** 36 (0.26)** 159 (1.17)**
  3 105 125 209 (1.67)** 63 (0.50)** 272 (2.18)**
  5 43 46 100 (2.17)** 29 (0.63)** 129 (2.80)**
Exp. 3
 mwh, ry506 × ry+ F1 females (uric acid +)
  0   92 128 (1.39) 11 (0.12) 139 (1.51)
  1   62 118 (1.90)** 30 (0.48)** 148 (2.39)**
 mwh, ry506 × ry506 F1 females (uric acid -)
  0   112 114 (1.31) 30 (0.34) 144 (1.66)
  1   50 131 (3.12)** 57 (1.36)** 188 (4.48)**
Exp. 4
 mwh, ry506 × ry+ F1 females (uric acid +)
  0 100 82 110 (1.34) 13 (0.16) 123 (1.50)
  1 87 88 135 (1.53) 28 (0.32) 163 (1.85)*
 mwh, ry506 × ry506 F1 females (uric acid -)
  0 100 90 123 (1.37) 15 (0.17) 138 (1.53)
  1 96 86 184 (2.14)** 51 (0.59)** 235 (2.73)**
  1. *P ≤ 0.05, **P ≤ 0.01, a significant increase in comparison to the corresponding control