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Table 6 Mutagenicity of NDEA in urate-null mutants and wild-type flies

From: Increase of somatic cell mutations in oxidative damage-sensitive drosophila

Dose (mM)

Survival (%)

No. of wings

No. of spots (spots/wing)

Small

Large

Total

Exp. 1

 y v ma-l; mwh × Oregon-R F1 females (uric acid +)

  0

100

140

17 (0.12)

2 (0.01)

19 (0.14)

  1

92

164

29 (0.18)

6 (0.04)

35 (0.21)

  3

90

158

38 (0.24)*

11 (0.07)

49 (0.31)**

  5

66

114

41 (0.36)**

6 (0.05)

47 (0.41)**

 y v ma-l; mwh × y v ma-l F1 females (uric acid -)

  0

100

135

49 (0.36)

6 (0.04)

55 (0.41)

  1

120

169

111 (0.66)**

21 (0.12)*

132 (0.78)**

  3

76

108

74 (0.69)**

25 (0.23)**

99 (0.92)**

  5

30

44

57 (1.30)**

16 (0.36)**

73 (1.66)**

Exp. 2

 y v ma-l; mwh × Oregon-R F1 females (uric acid +)

  0

100

151

19 (0.13)

4 (0.03)

23 (0.15)

  1

85

132

43 (0.33)**

19 (0.14)**

62 (0.47)**

  3

72

103

43 (0.42)**

14 (0.14)**

57 (0.55)**

  5

52

79

18 (0.23)

4 (0.05)

22 (0.28)

 y v ma-l; mwh × y v ma-l F1 females (uric acid -)

  0

100

117

46 (0.39)

11 (0.09)

57 (0.49)

  1

113

136

123 (0.90)**

36 (0.26)**

159 (1.17)**

  3

105

125

209 (1.67)**

63 (0.50)**

272 (2.18)**

  5

43

46

100 (2.17)**

29 (0.63)**

129 (2.80)**

Exp. 3

 mwh, ry506 × ry+ F1 females (uric acid +)

  0

 

92

128 (1.39)

11 (0.12)

139 (1.51)

  1

 

62

118 (1.90)**

30 (0.48)**

148 (2.39)**

 mwh, ry506 × ry506 F1 females (uric acid -)

  0

 

112

114 (1.31)

30 (0.34)

144 (1.66)

  1

 

50

131 (3.12)**

57 (1.36)**

188 (4.48)**

Exp. 4

 mwh, ry506 × ry+ F1 females (uric acid +)

  0

100

82

110 (1.34)

13 (0.16)

123 (1.50)

  1

87

88

135 (1.53)

28 (0.32)

163 (1.85)*

 mwh, ry506 × ry506 F1 females (uric acid -)

  0

100

90

123 (1.37)

15 (0.17)

138 (1.53)

  1

96

86

184 (2.14)**

51 (0.59)**

235 (2.73)**

  1. *P ≤ 0.05, **P ≤ 0.01, a significant increase in comparison to the corresponding control