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Table 7 Mutagenicity of NDMA in the presence or absence of uric acid in the diet

From: Increase of somatic cell mutations in oxidative damage-sensitive drosophila

NDMA (mM)

Addition of uric acid

Uric acid content in flies(nmol/mg protein)

No. of flies

No. of wings

No. of spots (spots/wing)

Small

Large

Total

y v ma-l; mwh × Oregon-R F1 females (uric acid +)

 0

–

256.6

79

100

9 (0.09)

2 (0.02)

11 (0.11)

+

321.2

69

100

7 (0.07)

2 (0.02)

9 (0.09)

 0.5

–

266.0

81

100

79 (0.79)

31 (0.31)

110 (1.10)

+

371.1

72

100

38 (0.38)§§

13 (0.13)§

51 (0.51) §§

y v ma-l; mwh × y v ma-l F1 females (uric acid -)

 0

–

0.08

68

100

23 (0.23)

6 (0.06)

56 (0.56)

+

11.3

38

66

12 (0.18)

4 (0.06)

16 (0.24)

 0.5

–

0.31

64

100

174 (1.74)

55 (0.55)

229 (2.29)

+

11.1

32

54

88 (1.63)

24 (0.44)

112 (2.07)

  1. §P < 0.05, §§ P < 0.01, a significant decrease in the presence of uric acid in comparison to in the absence of uric acid