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Table 7 Mutagenicity of NDMA in the presence or absence of uric acid in the diet

From: Increase of somatic cell mutations in oxidative damage-sensitive drosophila

NDMA (mM) Addition of uric acid Uric acid content in flies(nmol/mg protein) No. of flies No. of wings No. of spots (spots/wing)
Small Large Total
y v ma-l; mwh × Oregon-R F1 females (uric acid +)
 0 256.6 79 100 9 (0.09) 2 (0.02) 11 (0.11)
+ 321.2 69 100 7 (0.07) 2 (0.02) 9 (0.09)
 0.5 266.0 81 100 79 (0.79) 31 (0.31) 110 (1.10)
+ 371.1 72 100 38 (0.38)§§ 13 (0.13)§ 51 (0.51) §§
y v ma-l; mwh × y v ma-l F1 females (uric acid -)
 0 0.08 68 100 23 (0.23) 6 (0.06) 56 (0.56)
+ 11.3 38 66 12 (0.18) 4 (0.06) 16 (0.24)
 0.5 0.31 64 100 174 (1.74) 55 (0.55) 229 (2.29)
+ 11.1 32 54 88 (1.63) 24 (0.44) 112 (2.07)
  1. §P < 0.05, §§ P < 0.01, a significant decrease in the presence of uric acid in comparison to in the absence of uric acid