Fig. 1

In vitro-in vivo Correlation of Chemical Concentrations in Chromosomal Damage Tests. Red diamond shows in vivo positive compounds with their C_max and AUC_vivo being equal to or higher than in vitro LEC and AUC_vitro. Blue square shows in vivo negative compounds with their C_max and AUC_vivo being equal to or higher than in vitro LEC and AUC_vitro. Green triangle shows in vivo negative compounds with their C_max and/or AUC_vivo being less than in vitro LEC and AUC_vitro