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Table 1 Results of in vitro and in vivo studies with analyzed 18 compounds

From: Correlation between the results of in vitro and in vivo chromosomal damage tests in consideration of exposure levels of test chemicals

No.

Compound

Ames

in vitro test

in vivo test

Exposure dataa

1

A

TA100, TA98, TA1537

MN/CHL

+

MN/rat

+

Concomitant TK

2

B

TA100, TA98, TA2637, WP2uvrA

MN/CHL

+

MN/rat

+

PK

3

C

TA100, TA98, TA2637, WP2uvrA

MN/CHL

+

MN/rat

+

Concomitant TK

4

D

TA100, TA98

CA/CHL

+

MN/mouse

Concomitant TK

5

E

TA100, TA1535, TA98, TA1537, WP2uvrA

CA/CHL

+

MN/rat

TK

6

F

TA100, TA1535, TA98, TA1537, WP2uvrA

MN/CHL

+

MN/rat

Concomitant TK

7

G

TA100, TA98

MN/CHL

+

MN/rat

Concomitant TK

8

H

TA100, TA98, TA1537

MN/CHL

+

MN/rat

Concomitant TK

9

I

TA100, TA1535, TA98, TA1537, WP2uvrA

CA/CHL

+

MN/rat

TK

10

J

TA100, TA1535, TA98, TA1537, WP2uvrA

CA/CHL

+

CA/rat

Concomitant TK

11

K

TA100, TA98

CA/CHL

+

MN/rat

Concomitant TK

12

L

TA100, TA98

CA/CHL

+

MN/rat

Concomitant TK

13

M

TA100, TA1535, TA98, TA1537, WP2uvrA

MN/CHL

+

MN/rat

TK

14

N

TA100, TA1535, TA98, TA1537, WP2uvrA

MN/CHL

+

MN/rat

Concomitant TK

15

O

TA100, TA1535, TA98, TA1537, WP2uvrA

CA/CHL

+

MN/rat

Concomitant TK

16

P

TA100, TA1535, TA98, TA1537, WP2uvrA

MN/CHL

+

MN/rat

Concomitant TK

17

Q

TA100, TA1535, TA98, TA1537, WP2uvrA

 

MN/CHL

+

MN/rat

Concomitant TK

18

R

TA100, TA98, TA1537

MN/CHL

+

MN/rat

Concomitant TK

  1. MN, micronucleus test; CA, chromosomal aberration test; CHL, CHL/IU cells; PK, pharmacokinetic study; TK, toxicokinetics study
  2. +, positive; −, negative
  3. aIn case of no concomitant toxicokinetics study, exposure level was estimated from a reference study by using curve fitting