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Table 2 Comparison of dNTP molecules in a Molm-13 cell with those required to build a diploid genome

From: Simultaneous and absolute quantification of nucleoside triphosphates using liquid chromatography–triple quadrupole tandem mass spectrometry

   

Ratio of cellular dNTP molecules to those required to build a diploid genome (%)

Base

Substrate

Molecule number required to build a diploid genomea

Vehicle (100%b)

200 μM Thymidine (100% b)

2000 μM Thymidine (60%b)

A

dATP

3.82 × 109

0.121

0.083

0.171

G

dGTP

2.70 × 109

0.064

0.069

0.290

C

dCTP

2.61 × 109

0.162

0.109

0.077

T

dTTP

3.91 × 109

0.358

0.662

4.627

  1. aInformation of human genome size and composition of each base in the genome was obtained from Genome Reference Consortium Human Build 38 patch release 12 and [22], respectively
  2. bRelative cell number in each condition as shown in Fig. 2