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Table 1 Micronucleus induction in bone marrow of ddY mice 24 h after the treatment of 2,3-, 2,4-, 2,5-, 2,6-, 3,4- and 3,5-DMAs at 200 mg/kg bw

From: Mutagenic properties of dimethylaniline isomers in mice as evaluated by comet, micronucleus and transgenic mutation assays

Substance

MNPCEs/1000 PCEsa

Mean ± SD

PCE/NCE

Control

1

2

1

1.3 ± 0.5

1.1 ± 0.0

2,3-DMA

0

1

1

0.7 ± 0.5

0.8 ± 0.2

2,4- DMA

0

0

2

0.7 ± 0.9

1.1 ± 0.2

2,5- DMA

0

0

0

0.0 ± 0.0

1.1 ± 0.4

2,6- DMA

1

2

1

1.6 ± 0.9

1.0 ± 0.1

3,4- DMA

0

2

1

1.3 ± 0.5

1.1 ± 0.1

3,5-DMA

0

0

2

0.7 ± 0.9

0.9 ± 0.2

  1. MNPCE micronucleated polychromatic erythrocytes, NCE normochromatic erythrocytes
  2. adata from three mice