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Table 3 Spectra of mutations detected in the supF gene (experiment 1)a

From: Analysis of large deletion mutations induced by abasic site analog in human cells

  G GO THF  
point mutations at position 122
 G:C - > A:Tb 0 (0) 0 (0) 0 (0)  
 G:C - > T:Ac 3 (10) 23 (46) 9 (15)  
 G:C - > C:Gd 0 (0) 8 (16) 11 (18)  
 deletion 0 (0) 1 (2) 11 (18)  
mutations at other positions
 transition
  A:T - > G:C 1 (3) 0 (0) 0 (0)  
  G:C - > A:T 16 (53) 8 (16) 17 (28)  
 transversion
  A:T - > T:A 0 (0) 0 (0) 0 (0)  
  A:T - > C:G 3 (10) 2 (4) 0 (0)  
  G:C - > T:A 9 (30) 6 (12) 11 (18)  
  G:C - > C:G 4 (13) 4 (8) 19 (32)  
 small insertion (1–2 bp) 1 (3) 1 (2) 0 (0)  
 large insertion (> 2 bp) 6 (20) 1 (2) 1 (2)  
 small deletion (1–2 bp) 0 (0) 0 (0) 1 (2)  
 large deletion (> 2 bp) 12 (40) 8 (16) 12 (20)  
 others 0 (0) 0 (0) 2 (3)e  
total mutations 55 62 94  
total colonies analyzed 30 (100) 50 (100) 60 (100)  
  1. aAll data are represented as cases found (%)
  2. bThe mutation corresponds to incorporation of TMP opposite G/GO/THF
  3. cThe mutation corresponds to incorporation of dAMP opposite G/GO/THF
  4. dThe mutation corresponds to incorporation of dGMP opposite G/GO/THF
  5. eGG - > T at positions 121–122 and G - > AAGA at position 122