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Table 2 Mutation spectra of gpt mutations in the lungs of gpt delta mice administered the extracts

From: Change over time of the mutagenicity in the lungs of gpt delta transgenic mice by extract of airborne particles collected from ambient air in the Tokyo metropolitan area

Type of mutation in gpt

Control

1980

1990

2010

All (1980 + 1990 + 2010)

control

0.3 mg

0.6 mg

0.9 mg

All (0.3 + 0.6 + 0.9)

control

0.15 mg

0.3 mg

0.6 mg

All (0.15 + 0.3 + 0.6)

control

0.15 mg

0.3 mg

0.6 mg

All (0.15 + 0.3 + 0.6)

Number

%

Number

%

Number

%

Number

%

Number

%

Number

%

Number

%

Number

%

Number

%

Number

%

Number

%

Number

%

Number

%

Number

%

Number

%

Number

%

Base substitution

                                

 Transition

  G:C → A:T

41

44

18

40

12

48

23

43

5

23

40

40

6

46

8

33

14

50

5

56

27

44

17

49

7

41

14

56

20

31

41

39

  (CpG site)

(29)

 

(12)

 

(8)

 

(14)

 

(0)

 

(22)

 

(4)

 

(5)

 

(12)

 

(3)

 

(20)

 

(13)

 

(6)

 

(10)

 

(12)

 

(28)

 

  A:T → G:C

9

10

4

9

1

4

6

11

2

9

9

9

2

15

1

4

1

4

0

0

2

3

3

9

1

6

1

4

2

3

4

4

 Transversion

  G:C → T:A

17

18

9

20

7

28

9

17

6

27

22

22

2

15

9

38

2

7

1

11

12

20

6

17

4

24

5

20

26

41

35

33

  G:C → C:G

1

1

0

0

1

4

2

4

1

5

4

4

0

0

1

4

1

4

1

11

3

5

1

3

0

0

0

0

1

2

1

1

  A:T → T:A

2

2

0

0

0

0

0

0

2

9

2

2

1

8

2

8

0

0

1

11

3

5

1

3

0

0

0

0

0

0

0

0

  A:T → C:G

6

6

4

9

1

4

3

6

0

0

4

4

0

0

1

4

2

7

0

0

3

5

2

6

0

0

0

0

1

2

1

1

 Deletion

  1

15

16

8

18

2

8

7

13

3

14

12

12

2

15

2

8

4

14

0

0

6

10

5

14

4

24

4

16

9

14

17

16

  ≥2

1

1

1

2

0

0

1

2

0

0

1

1

0

0

0

0

0

0

1

11

1

2

0

0

0

0

1

4

1

2

2

2

 Insertion

1

1

1

2

1

4

1

2

2

9

4

4

0

0

0

0

4

14

0

0

4

7

0

0

1

6

0

0

2

3

3

3

 Other

0

0

0

0

0

0

1

2

1

5

2

2

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

2

3

2

2

 Total

93

100

45

100

25

100

53

100

22

100

100

100

13

100

24

100

28

100

9

100

61

100

35

100

17

100

25

100

64

100

106

100

  1. ‘All’ indicates combined data of mice treated with the different concentrations of extract. The column of ‘All (1980 + 1990 + 2010)’ indicates the sum of number of each mutation in the control for 1980, 1990 and 2010, and the percentage of each mutation