Type of mutation in gpt | Control | 1980 | 1990 | 2010 | ||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
All (1980 + 1990 + 2010) | control | 0.3 mg | 0.6 mg | 0.9 mg | All (0.3 + 0.6 + 0.9) | control | 0.15 mg | 0.3 mg | 0.6 mg | All (0.15 + 0.3 + 0.6) | control | 0.15 mg | 0.3 mg | 0.6 mg | All (0.15 + 0.3 + 0.6) | |||||||||||||||||
Number | % | Number | % | Number | % | Number | % | Number | % | Number | % | Number | % | Number | % | Number | % | Number | % | Number | % | Number | % | Number | % | Number | % | Number | % | Number | % | |
Base substitution | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 Transition | ||||||||||||||||||||||||||||||||
  G:C → A:T | 41 | 44 | 18 | 40 | 12 | 48 | 23 | 43 | 5 | 23 | 40 | 40 | 6 | 46 | 8 | 33 | 14 | 50 | 5 | 56 | 27 | 44 | 17 | 49 | 7 | 41 | 14 | 56 | 20 | 31 | 41 | 39 |
  (CpG site) | (29) |  | (12) |  | (8) |  | (14) |  | (0) |  | (22) |  | (4) |  | (5) |  | (12) |  | (3) |  | (20) |  | (13) |  | (6) |  | (10) |  | (12) |  | (28) |  |
  A:T → G:C | 9 | 10 | 4 | 9 | 1 | 4 | 6 | 11 | 2 | 9 | 9 | 9 | 2 | 15 | 1 | 4 | 1 | 4 | 0 | 0 | 2 | 3 | 3 | 9 | 1 | 6 | 1 | 4 | 2 | 3 | 4 | 4 |
 Transversion | ||||||||||||||||||||||||||||||||
  G:C → T:A | 17 | 18 | 9 | 20 | 7 | 28 | 9 | 17 | 6 | 27 | 22 | 22 | 2 | 15 | 9 | 38 | 2 | 7 | 1 | 11 | 12 | 20 | 6 | 17 | 4 | 24 | 5 | 20 | 26 | 41 | 35 | 33 |
  G:C → C:G | 1 | 1 | 0 | 0 | 1 | 4 | 2 | 4 | 1 | 5 | 4 | 4 | 0 | 0 | 1 | 4 | 1 | 4 | 1 | 11 | 3 | 5 | 1 | 3 | 0 | 0 | 0 | 0 | 1 | 2 | 1 | 1 |
  A:T → T:A | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 9 | 2 | 2 | 1 | 8 | 2 | 8 | 0 | 0 | 1 | 11 | 3 | 5 | 1 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
  A:T → C:G | 6 | 6 | 4 | 9 | 1 | 4 | 3 | 6 | 0 | 0 | 4 | 4 | 0 | 0 | 1 | 4 | 2 | 7 | 0 | 0 | 3 | 5 | 2 | 6 | 0 | 0 | 0 | 0 | 1 | 2 | 1 | 1 |
 Deletion | ||||||||||||||||||||||||||||||||
  1 | 15 | 16 | 8 | 18 | 2 | 8 | 7 | 13 | 3 | 14 | 12 | 12 | 2 | 15 | 2 | 8 | 4 | 14 | 0 | 0 | 6 | 10 | 5 | 14 | 4 | 24 | 4 | 16 | 9 | 14 | 17 | 16 |
  ≥2 | 1 | 1 | 1 | 2 | 0 | 0 | 1 | 2 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 11 | 1 | 2 | 0 | 0 | 0 | 0 | 1 | 4 | 1 | 2 | 2 | 2 |
 Insertion | 1 | 1 | 1 | 2 | 1 | 4 | 1 | 2 | 2 | 9 | 4 | 4 | 0 | 0 | 0 | 0 | 4 | 14 | 0 | 0 | 4 | 7 | 0 | 0 | 1 | 6 | 0 | 0 | 2 | 3 | 3 | 3 |
 Other | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 1 | 5 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 3 | 2 | 2 |
 Total | 93 | 100 | 45 | 100 | 25 | 100 | 53 | 100 | 22 | 100 | 100 | 100 | 13 | 100 | 24 | 100 | 28 | 100 | 9 | 100 | 61 | 100 | 35 | 100 | 17 | 100 | 25 | 100 | 64 | 100 | 106 | 100 |