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Table 3 List of the results in genotoxicity tests for the 454 designated food additives (As of October 6, 2016)

From: Summarized data of genotoxicity tests for designated food additives in Japan

No.a Name Functional classes CAS# Molecular weight Genotoxicity tests Remarks
Ames CA MN TGR Others
1 zinc salts (limited to zinc gluconate and zinc sulfate) Dietary supplement    -(13) -H23 c     
2 b chlorous acid water Sterilizer 13898–47-0 68.45 +FSC1 d +FSC1 -FSC1    
3 [20] sodium chlorite Bleaching agent etc. 7758-19-2 90.44 +(2)-(12) +(2) +(9)    
4 nitrous oxide Propellantt 10024–97-2 44.01 -FSC2      
5 adipic acid Acidifier 124–04-9 146.14 -(15) -H22     
6 sodium nitrite Color fixative 7632–00-0 69.00 +(1) -(16) +(1) -(9) -H21   Target organs for TG in mice: liver, stomach (glandular stomach)
7 l-ascorbic acid (vitamin C) Antioxidant etc. 50–81-7 176.12 -(1)(10) -(1)     
8 calcium l -ascorbate Dietary supplement etc. 5743-28-2 426.35 -FSC3      
9 l-ascorbic acid 2-glucoside Antioxidant etc. 129499–78-1 338.26 -H26 -H26 -FSC4    
10 l-ascorbic stearate (vitamin C stearate) Antioxidant etc. 25395–66-8 442.59 -(4)(16) -(4)     
11 sodium l-ascorbate (vitamin C sodium) Antioxidant etc. 134–03-2 198.11 -H20 -H20 -H20    
12 l-ascorbic palmitate (vitamim C palmitate) Antioxidant etc. 137–66-6 414.53 -(17) -H22     
13 asparaginase Processing agent 9015–68-3   -FSC5 -FSC5     
14 monosodium l -aspartate Seasoning etc. 3792-50-5 173.10 -(3)(17) -(3)     
15 aspartame (α- l -aspartyl- l -phenylalanine methyl ester) Sweetener 22839–47-0 294.30 -(16) -H23     
16 [21, 22] acesulfame potassium Sweetener etc. 55589–62-3 201.24 - (21) - (22)     
17 acetylated distarch adipate Thickening agents etc. 68130–14-3        Evaluated as modified starch
18 acetylated oxidized starch Thickening agents etc. 68187–08-6        Evaluated as modified starch
19 acetylated distarch phosphate Thickening agents etc.        Evaluated as modified starch
20 acetaldehyde Flavoring agent etc. 75–07-0 44.05 -FSC6 +FSC6     
21 ethyl acetoacetate Flavoring agent 141–97-9 130.14 -(3)(12) -(3)     
22 acetophenone Flavoring agent 98–86-2 120.15 -(12)      
23 acetone Processing agent 67–64-1 58.08 -(1)(17) +(1)     
24 sodium selenite pentahydrate Dietary supplement 10102–18-8 172.94 +FSC7 +FSC7 +FSC7    
25 azoxystrobin Preservative etc. 131860–33-8 403.4 -FSC8   -FSC8    
26 advantame Sweetener 714229–20-6 476.52 -FSC9   -FSC9    
27 anisaldehyde (p-methoxybenzaldehyde) Flavoring agent 123–11-5 136.15 -(2)(12) -(2)     
28 β-apo-8′-carotenal Food color 1107–26-2 416.64 -FSC10 -FSC10 -FSC10    
29 (3-amino-3-carboxypropyl) dimethylsulfonium chloride Flavoring agent 3493-12-7 199.7 -H21 -H21 -H21    
30 amylalcohol Flavoring agent 71–41-0 88.15 - H16 - H16     
31 α-amylcinnamaldehyde (α-amylcinnamic aldehyde) Flavoring agent 122–40-7 202.29 -(12) -H24     
32 dl-alanine Seasoning etc. 302–72-7 89.09 -(3)(17) -(3)     
33 sodium sulfite Preservative etc. 7757-83-7 126.04 -(1)(12) -(1)     Crystalline form and anhydrous form were used for tests in (1) and (12), respectively.
34 l -arginine l -glutamate Seasoning etc. 4320–30-3 321.33 -(4)(20) -(4)     
35 ammonium alginate Emulsifier etc. 9005–34-9   -FSC11      
36 potassium alginate Emulsifier etc. 9005–36-1   -FSC12      
37 calcium alginate Emulsifier etc. 9005–35-0        See compounds with different salt
38 [23] sodium alginate Thickening agents 9005–38-3   -(2)(8)(18) -(2)     
39 propylene glycol alginate Thickening agents    -(2)(13) -(2)     
40 benzoic acid Preservative 65–85-0 122.12 -(2)(11) -(2)     
41 sodium benzoate Preservative 532–32-1 144.10 -(1)(19) +(1) -H20    
42 methyl anthranilate Flavoring agent 134–20-3 151.16 -(12) +H22     
43 ammonia Processing agent 7664-41-7 17.03 -(18)      
44 ammonium isovalerate Flavoring agent 1449430–58-3 323.43 -H17 -H17     
45 ionone Flavoring agent 8013-90-9 192.30 -(20) -H24     Mixture of α and β-ionone were used for the assay
46 ion exchange resin Processing agent         
47 isoamylalcohol Flavoring agent 123–51-3 88.15 - H16 - H16 - H16    
48 isoeugenol Flavoring agent 97–54-1 164.20 -(12) -H23     
49 isoamyl isovalerate Flavoring agent 659–70-1 172.26 -(3)(12) -(3)     
50 ethyl isovalerate Flavoring agent 108–64-5 130.18 -(3)(12) -(3)     
51 isoquinoline Flavoring agent 119–65-3 129.16   +H18 -H21    
52 [24] isothiocyanates (except those generally recognized as highly toxic) Flavoring agent 542–85-8   -(19)      Ethyl thiocyanate was used for the assay.
53 allyl isothiocyanate (volatile oil of mustard) Flavoring agent 57–06-7 99.16 -(12) +H22     
54 isovaleraldehyde Flavoring agent 590–86-3 86.13 -FSC13   - H17    
55 isobutanol Flavoring agent 78–83-1 74.12 -FSC14 - H16     
56 isobutyraldehyde (isobutanal) Flavoring agent 78–84-2 72.11 -FSC15 +FSC15 -FSC15    
57 isopropanol Processing agent etc. 67–63-0 60.10 -FSC16   -FSC16    
58 isopentylamine Flavoring agent 107–85-7 87.16 -H18 -H18 -H18    
59 [25] l -isoleucine Dietary supplement 73–32-5 131.17 -(3)(15) -(3)     
60 disodium 5′-inosinate (sodium 5′-inosinate) Seasoning etc. 4691–65-0 392.17 -(1)(17) +(1) -H20    
61 imazalil Antimolding agent 35554–44-0 297.18 -(20)      
62 indoles and its derivatives Flavoring agent 120–72-9 (indole)   -(19)-H26 -H23     
63 disodium 5′-uridylate (sodium 5′-uridylate) Seasoning etc. 3387–36-8 368.15 -(1)(17) +(1) -H22    
64 γ-undecalactone (undecalactone) Flavoring agent 104–67-6 184.28 -(3)(12) -(3) -(9)    
65 ester gum Chewing gum base    -(2) -(2)     
66 esters Flavoring agent    -(2) or (4) -(2) or (4)     Cinnamyl anthranilate, ethyl caprylate, allyl caproate, ethyl caproate were included.
67 mixture of 2-ethyl-3,5-dimethylpyrazine and 2-ethyl-3,6-dimethylpyrazine Flavoring agent 55031–15-7 136.20 -FSC17      
68 ethylvanillin Flavoring agent 121–32-4 166.17 -(2)(12) -(2)     
69 2-ethylpyrazine Flavoring agent 13925–00-3 108.14    +H16    
70 3-ethylpyridine Flavoring agent 536–78-7 107.15   +H16 -H17    
71 2-ethyl-3-methylpyrazine Flavoring agent 15707–23-0 122.17 - H16 - H16 - H16    
72 2-ethyl-5-methylpyrazine Flavoring agent 13360–64-0 122.17 - H16 - H16     
73 2-ethyl-6-methylpyrazine Flavoring agent 13925–03-6 122.17 - H17 - H17     The test substrate was mixture with 2-ethyl-5-methylpyrazine.
74 5-ethyl-2-methylpyridine Flavoring agent 104–90-5 121.18 -FSC18   -FSC18    
75 calcium disodium ethylenediaminetetraacetate (calcium disodium edta) Antioxidant 62–33-9 410.30 -(13) -H22     
76 disodium ethylenediaminetetraacetate (disodium, EDTA) Antioxidant 6381-92-6 372.24 -(13)      
77 ethers Flavoring agent         
78 erythorbic acid (isoascorbic acid) Antioxidant 89–65-6 176.12 +(2) -(17) -(2) -(9) -H21   Target organs for TGR in mice:liver, stomach (glandular stomach)
79 sodium erythorbate (sodium isoascorbate) Antioxidant 6381–77-7 216.12 -(1)(14) -(1)     
80 ergocalciferol (calciferol or vitamin D2) Dietary supplement 50–14-6 396.65 -(1)(20) -(1)     
81 ammonium chloride Raising agent 12125–02-9 53.49 -(2)(16) +(2) -(9)    
82 potassium chloride Seasoning 7447-40-7 74.55 -(17) -H23     
83 calcium chloride Tofu coagulator etc. 10043–52-4 110.98 -(1)(12) -(1)     
84 ferric chloride Dietary supplement 10025–77-1 270.29 -(4)(15) -(4)     
85 magnesium chloride Tofu coagulator etc. 7791-18-6 203.30 -(4)(5)(18) -(4)     
86 hydrochloric acid Processing agent 7647–01-0 36.46 -(16)      
87 eugenol Flavoring agent 97–53-0 164.20 -(2)(14) +(2) -(9)    
88 octanal (capryl aldehyde or octyl aldehyde) Flavoring agent 124–13-0 128.21 -(14) -H22     
89 octanoic acid Flavoring agent 124–07-2   -FSC19      
90 ethyl octanoate (ethyl caprylate) Flavoring agent 106–32-1 172.26 -(14) -H25     
91 starch sodium octenyl succinate Thickening agents etc.   -FSC20      
92 o -phenylphenol and sodium o -phenylphenate Antimolding agent 90–43-7 170.21 -(1)      o -phenylphenol was negative in CA
93 sodium oleate Film-forming agent 143–19-1 304.44 -(14)      
94 peracetic acid Preservative etc. 79–21-0   +FSC21 +FSC21 -FSC21    
95 hydrogen peroxide Sterilizer 7722-84-1 34.01 -(1)(16) +(1) -H21    
96 benzoyl peroxide Flour treatment agent 94–36-0 242.23 -(1)(12) -(1)     
97 sodium caseinate Processing agent 9005-46-3   -(5)(18) -(5)     
98 ammonium persulfate Flour treatment agent 7727-54-0 228.20 -(2)(12) -(2)     
99 calcium carboxymethylcellulose (calcium cellulose glycolate) Thickening agents 9050-04-8   -(4) -(4)     
100 sodium carboxymethylcellulose (sodium cellulose glycolate) Thickening agents 9004-32-4   -(1)(13) -(1)     
101 β-carotene Food color etc. 7235-40-7 536.88 -(1)(13) ±(1)     
102 canthaxanthin Food color 514–78-3 564.82 -FSC22 -FSC22 -FSC22    
103 isoamyl formate Flavoring agent 110–45-2 116.16 -(3)(16) -(3)     
104 geranyl formate Flavoring agent 105–86-2 182.26 -(14) -H24     
105 citronellyl formate Flavoring agent 105–85-1   -(20) -H24     
106 [26] xylitol Sweetener 87–99-0 152.15 - (23)   - (23)    
107 disodium 5′-guanylate (sodium 5′-guanylate) Flavoring agent etc. 5550-12-9 407.18 -(3)(17) -(3)     
108 citric acid Acidifier 77–92-9 192.12 -(1)(15) -(1)     Crystalline form and anhydrous form were used for tests in (1) and (5), respectively.
109 isopropyl citrate Antioxidant 39413–05-3   -(13)      
110 triethyl citrate Sweetener 77–93-0 276.28 -H26 -H26 -H26    
111 monopotassium citrate and tripotassium citrate Flavoring agent etc. 866–83-1 230.21 -(17) -(8)-H25    Rec assay: +(8) monopotassium citrate and tripotassium citrate were used in (17), monopotassium citrate was used in (8), tripotassium citrate was used in H25
112 calcium citrate Dietary supplement etc. 813–94-5 570.49 -(5)(13) -(5)     
113 sodium ferrous citrate (sodium iron citrate) Dietary supplement 50717–86-7 526.01 -H22 +H22     
114 ferric citrate Dietary supplement 77–92-9 192.12 -(4)(15) -(4)     
115 ferric ammonium citrate Dietary supplement 1185–57-5   -(4)(15) -(4)     
116 trisodium citrate (sodium citrate) Acidifier 68–04-2 258.07 -(17) -(1)     
117 glycine Seasoning etc. 56–40-6 75.07 -(3)(19) -(3)     Crystalline form and powdery form were used for tests in (3), and Crystalline form for (19)
118 glycerol (glycerin) Processing agent 56–81-5 92.09 -(2)(19) -(2)     
119 glycerol esters of fatty acids Emulsifier    -(1) -(1)     
120 calcium glycerophosphate Dietary supplement 27214–00-2 210.14 -(2)(12) -(2)     
121 disodium glycyrrhizinate Sweetener 68797–35-3 899.11 -(1) +(1) -(9)    
122 glucono-delta-lactone (gluconolactone) Acidifier 90–80-2 178.14 -(1)(15) -(1)     
123 gluconic acid Acidifier 526–95-4 196.16 -(4)(15) -(4)     
124 potassium gluconate Acidifier 299–27-4 234.25   -(8)    Rec assay: -(8)  
125 calcium gluconate Dietary supplement 299–28-5 448.39 -(5)(12) -(5)     
126 ferrous gluconate (iron gluconate) Dietary supplement etc. 299–29-6 446.14 -(19) +H25     
127 sodium gluconate Emulsifier etc. 527–07-1 218.14       See substrates with different salt
128 glutamyl-valyl-glycine Seasoning 38837–70-6 303.31 -FSC23 -FSC23 -FSC23    
129 l-glutamic acid Seasoning 56–86-0 147.13 -(5)(19) -(5)     
130 monoammonium l-glutamate Seasoning etc. 7558-63-6 182.18 -FSC24     Rec assay: -FSC24  
131 monopotassium l-glutamate Seasoning etc. 6382-01-0 203.23 -(17) -H25     
132 monocalcium di-l-glutamate Dietary supplement etc. 69704–19-4 404.38       See substrate with different salt
133 monosodium l-glutamate Seasoning etc. 6106-04-3 187.13 -(1)(19) -(1)     
134 monomagnesium di- l-glutamate Dietary supplement etc. 129160–51-6 388.61       See substrate with different salt
135 calcium silicate Processing agent 38837–70-6   -FSC25 -FSC25     
136 magnesium silicate Processing agent 1343-88-0   -FSC26      
137 cinnamic acid Flavoring agent 140–10-3 148.16 -(14) -H23     
138 ethyl cinnamate Flavoring agent 103–36-6 176.21 -(2)(14) -(2)     
139 methyl cinnamate Flavoring agent 103–26-4 162.19 -(14) +H23     
140 ketones Flavoring agent         
141 geraniol Flavoring agent 106–24-1 154.25 -(2)(14) -(2)     
142 high test hypochlorite bleaching agent etc.    +(3) -(20) +(3) -(4)    
143 succinic acid Acidifier etc. 110–15-6 118.09 -(1)(15) -(1)     
144 monosodium succinate Seasoning etc. 2922-54-5 140.07 -(19) -H23-H26     
145 disodium succinate Seasoning etc. 150–90-3 162.05 -(1)(19) ±(1)     
146 cholecalciferol (vitamin D3) Dietary supplement 67–97-0 384.64 -(3)(20) -(3)     
147 sodium chondroitin sulfate Humectant etc. 12678–07-8   -(3)(14) -(3)     
148 isoamyl acetate Flavoring agent 123–92-2 130.18 -(3)(14) -(3)     
149 ethyl acetate Flavoring agent etc. 141–78-6 88.11 -(1)(16) +(1) -(9)    
150 calcium acetate Dietary supplement etc. 62–54-4 158.17       See substrates with different salt
151 geranyl acetate Flavoring agent 105–87-3 196.29 -(14) -H24     
152 cyclohexyl acetate Flavoring agent 622–45-7 142.20 -(14) -H25     
153 citronellyl acetate Flavoring agent 150–84-5 198.30 -(14) -H24     
154 cinnamyl acetate Flavoring agent 103–54-8 176.21 -(14) +H24     
155 terpinyl acetate Flavoring agent 8007-35-0 196.29 -(14) -H24     
156 starch acetate Thickening agents etc. 9045–28-7   -FSC20 -FSC20 -FSC20    
157 sodium acetate Acidifier etc. 127–09-3 82.03 -(2)(18) -(2)     Crystalline form was used in (2), and anhydrous form was used in (18).
158 polyvinyl acetate Chewing gum base etc.    -(3)(14) -(3)     
159 phenethyl acetate (phenylethyl acetate) Flavoring agent 103–45-7 164.20 -(15) -H24     
160 butyl acetate Flavoring agent 123–86-4 116.16 -(3)(15) -(3)     
161 benzyl acetate Flavoring agent 140–11-4 150.17 -(4)(15) -(4)     
162 l-menthyl acetate Flavoring agent 2623-23-6 198.30 -(15) -H22     
163 linalyl acetate Flavoring agent 115–95-7 196.29 -(15) -H23     
164 saccharin Sweetener 81–07-2 183.19 -(2)(14) -(2)     
165 calcium saccharin Sweetener 6381-91-5 467.48   +FSC27     
166 [27] sodium saccharin (soluble saccharin) Sweetener 128–44-9 205.17 -(1)(11) +(1) -H21    
167 methyl salicylate Flavoring agent 119–36-8 152.15 -(2)(15) -(2)     
168 calcium oxide Processing agent 1305-78-8 56.08 -FSC28      
169 oxidized starch Thickening agents etc.   -FSC20 -FSC20 -FSC20    
170 magnesium oxide Absorbent etc. 1309–48-4 40.30 -(13) -H22     
171 [28] iron sesquioxide (diiron trioxide or iron oxide red) Food color 1309–37-1 159.69 -(4)(6)(19) -(4) -(8)   Rec assay: -(6)  
172 hypochlorous acid water Preservative    - H6      
173 sodium hypochlorite (hypochlorite of soda) Sterilizer etc. 7681–52-9 74.44 +(1) -(12) +(1) -(9)    
174 hypobromous acid water Sterilizer 13517–11-8 96.91 -FSC29 -FSC29     5,5-Dimethylhydantoin was used for the assays.
175 sodium hydrosulfite (hydrosulfite) bleaching agent etc. 7775–14-6 174.11 -(2)(12) -(2)     
176 2,3-diethylpyrazine Flavoring agent 15707–24-1 136.19 -H15 +H15 +H16    
177 2,3-diethyl-5-methylpyrazine Flavoring agent 18138–04-0 150.22 -H17 -H17 -H18    
178 allyl cyclohexylpropionate Flavoring agent 2705-87-5 196.29 -(15) -H22     
179 l-cystein monohydrochloride Antioxidant etc. 7048–04-6 175.64 +(4)(14) +(4) -(9) -H21   Target organs for TGR in mice:liver, stomach (glandular stomach)
180 disodium 5′-cytidylate (sodium 5′-cytidylate) Seasoning 6757–06-8 367.16 -(1)(19) +(1) -H22    
181 citral Flavoring agent 5392–40-5 152.23 -(3)(4)(14) -(3)(4)     
182 citronellal Flavoring agent 106–23-0 154.25 -(15) -(5) -(8)    
183 citronellol Flavoring agent 106–22-9 156.27 -(15) -H22     
184 1,8-cineole (eucalyptol) Flavoring agent 470–82-6 154.25 -(15) -H22     
185 [29] diphenyl (biphenyl) Antimolding agent 92–52-4 154.21 -(1)(10) -(1)     
186 butylated hydroxytoluene Antioxidant 128–37-0 220.35 -(10) -(1)     
187 dibenzoyl thiamine Dietary supplement 299–88-7 490.58 -(5)(12) -(5)     
188 dibenzoyl thiamine hydrochloride Dietary supplement 35660–60-7 527.04 -(1)-H26 -(1)+H26     
189 fatty acids Flavoring agent         
190 aliphatic higher alcohols Flavoring agent    -(14)      
191 aliphatic higher aldehydes (except those generally recognized as highly toxic) Flavoring agent         
192 aliphatic higher hydrocarbons (except those generally recognized as highly toxic) Flavoring agent         
193 2,3-dimethylpyrazine Flavoring agent 5910-89-4 108.14 -FSC30 -H16     
194 2,5-dimethylpyrazine Flavoring agent 123–32-0 108.14 -FSC31   -H16    
195 2,6-dimethylpyrazine Flavoring agent 108–50-9 108.14 -FSC32   -H16    
196 2,6-dimethylpyridine Flavoring agent 108–48-5 107.15 -FSC33 -H18 -H18    
197 oxalic acid Processing agent 6153-56-6 126.07 -(3)(13) -(3)     
198 potassium bromate Flour treatment agent 7758-01-2 167.00 +(1) -(12) +(1) +(9)    
199 dl-tartaric acid (dl -tartaric acid) Acidifier 133–37-9 150.09 -(15) -H23     
200 l-tartaric acid (d -tartaric acid) Acidifier 87–69-4 150.09 -(2)(15) - (2)     Identical to d-tartaric acid
201 potassium dl-bitartrate (potassium hydrogen dl-tartrate or potassium hydrogen dl-tartrate) Processing agent etc.    -H22 -H22     
202 potassium l-bitartrate (potassium hydrogen l-tartrate or potassium hydrogen d -tartrate) Raising agent 868–14-4 188.18 -(2)(19) - (2)     Identical to potassium hydrogen d-tartarate
203 disodium dl-tartrate (disodium dl-tartrate) Processing agent etc.         
204 disodium l-tartrate (disodium l -tartrate) Seasoning 6106-24-7 194.05 -(1)(19) +(1) -(9)    Identical to disodium d-tartarate
205 potassium nitrate Fermentation regulator etc. 7757-79-1 101.10 -(4)(13) -(4)     
206 sodium nitrate Fermentation regulator etc. 7631-99-4 84.99 -(1)(13) +(1) -H21    
207 food red no.2 (amaranth) and its aluminum lake Food color 915–67-3 604.48 -(1)(18) +(1)     
208 food red no.3 (erythrosine) and its aluminum lake Food color 16423–68-0 897.87 -(1)(18) +(1) - (2)    
209 food red no.40 (allura red ac) and its aluminum lake Food color 25956–17-6 496.42 -(20)   -H20 -H20, -H23 Comet: -H20, -H23 Target organs for Comet in mice:liver, stomach (glandular stomach).Target organs for TGR in mice:liver, stomach (glandular stomach) for (H20), liver, colon for (H23)
210 food red no.102 (new coccine) Food color 2611–82-7 631.50 -(1)(18) +(1) - (2) -H20 Comet: (+)H20 Target organs for Comet in mice:liver; pseudo positive, stomach (glandular stomach); negative.
Target organs for TGR in mice:liver, stomach (glandular stomach)
211 food red no.104 (phloxine) Food color 18472–87-2 829.63 -(1)(18) -(1)   -H20 Comet: +H20 Target organs for Comet in mice:liver; pseudo positive, stomach (glandular stomach) in mice; positive.
Target organs for TGR in mice:liver, stomach (glandular stomach)
212 food red no.105 (rose bengale) Food color 632–69-9 1017.64 -(1)(18) -(1)   -H20 Comet: +H20 Target organs for Comet:liver, stomach (glandular stomach) in mice, positive for both.
Target organs for TGR in mice:liver, stomach (glandular stomach)
213 food red no.106 (acid red) Food color 3520-42-1 580.65 -(1)(18) +(1) - (2)    
214 food yellow no.4 (tartrazine) and its aluminum lake Food color 1934-21-0 534.37 -(1)(18) +(1) - (9)    
215 food yellow no.5 (sunset yellow fcf) and its aluminum lake Food color 2783-94-0 452.37 -(1)(18) +(1) -H21    
216 food green no.3 (fast green fcf) and its aluminum lake Food color 2353-45-9 808.85 -(1)(18) -(1) -(2)    High purity sample was used in (1).
217 food blue no.1 (brilliant blue fcf) and its aluminum lake Food color 3844-45-9 792.85 -(1)(18) +(1) -H21    
218 food blue no.2 (indigo carmine) and its aluminum lake Food color 860–22-0 466.35 -(1)(18) +(1)     
219 sucrose esters of fatty acids Emulsifier    -(1)(20) ±(1)     
220 silicone resin (polydimethylsiloxane) Antiforming agent    -(2) - (2)     
221 cinnamyl alcohol (cinnamic alcohols) Flavoring agent 104–54-1 134.18 -(16) +H24     
222 cinnamaldehyde (cinnamic aldehyde) Flavoring agent 14371–10-9 132.16 +(3)(14) +(3) -(9) -H22   Target organs for TGR:liver, small intestine (Jejunum) in mice
223 potassium hydroxide (caustic potash) Processing agent 1310-58-3 56.11 -(17)      
224 calcium hydroxide (slaked lime) Processing agent etc. 1305-62-0 74.09 -(5)(14) -(5)     
225 sodium hydroxide (caustic soda) Processing agent 1310-73-2 40.00 -(16)      
226 magnesium hydroxide Dietary supplement etc. 1309–42-8 58.32 -FSC34      
227 [30] sucralose (trichlorogalactosucrose) Sweetener 56038–13-2 397.64 - (24)   - (24)    
228 calcium stearate Dietary supplement 1592–23-0 324.56       
229 magnesium stearate Emulsifier etc. 557–04-0 591.24 -H13 -H13 -H13    See calcium stearate
230 calcium stearoyl lactylate (calcium stearyl lactylate) Emulsifier 5793-94-2   -(3) -(3)     
231 sodium stearoyl lactylate Emulsifier etc. 25383–99-7 378.53       See calcium stearoyl lactylate
232 sorbitan esters of fatty acids Emulsifier    -(1)(20) ±(1)     
233 d-sorbitol (d-sorbit) Sweetener etc. 50–70-4 182.17 -(1)(11) -(1)     d-Sorbit WP was also used in (1).
234 sorbic acid Preservative 110–44-1 112.13 -(2)(16) -(2)     
235 potassium sorbate Preservative 24634–61-5 150.22 -(1)(11) +(1) -H20    
236 calcium sorbate Preservative etc. 7492-55-9 262.32       See potassium sorbate
237 ammonium carbonate Processing agent etc. 506–87-6 96.09 -(19) -H23     
238 potassium carbonate (anhydrous) Processing agent etc. 584–08-7 138.21 -(4)(19) -(4)     
239 calcium carbonate Processing agent etc. 471–34-1 100.09 -(12) +H23     
240 ammonium bicarbonate (ammonium hydrogen carbonate) Raising agent etc. 1066-33-7 79.06 -(4)(19) -(4)     
241 sodium bicarbonate (bicarbonate soda or sodium hydrogen carbonate) Raising agent etc. 144–55-8 84.01 -(2)(19) -(2)     
242 sodium carbonate (crystal: carbonate soda, anhydrous: soda ash) Processing agent 497–19-8 105.99 -(3)(19) -(3)     Crystalline form was used in (3), and anhydrous form was used for in (19).
243 magnesium carbonate Processing agent 546–93-0 84.31 -(5)(13) -(5)     
244 thiabendazole Antimolding agent 148–79-8 201.25 -(1)(10) -(1)     
245 thiamine hydrochloride (vitamin B1 hydrochloride) Dietary supplement 67–03-8 337.27 -(2)(11) -(2)     
246 thiamine mononitrate (vitamin B1 mononitrate) Dietary supplement 532–43-4 327.36 -(5)(15) -(5)     
247 thiamine dicetylsulfate (vitamin B1 dicetylsulfate) Dietary supplement    -(1) -(1)     
248 thiamine thiocyanate (vitamin B1 thiocyanate) Dietary supplement 130131–60-1 341.45       See thiamine hydrochloride
249 thiamine naphthalene-1,5-disulfonate (vitamin B1naphthalene-1,5-disulfonate) Dietary supplement    -(2) -(2)     
250 thiamine dilaurylsulfate (vitamin B1 dilaurylsulfate) Dietary supplement etc.    -(2) -(2)     
251 thioethers (except those generally recognized as highly toxic) Flavoring agent         
252 thiols (thioalcohols) (except those generally recognized as highly toxic) Flavoring agent         
253 l -theanine Seasoning 3081-61-6 174.20 -(4)(19) -(4)     
254 decanal (decyl aldehyde) Flavoring agent 112–31-2 156.27 -(3)(16) -(3)     
255 decanol (decyl alcohol) Flavoring agent 112–30-1 158.28 -(16) -H25     
256 ethyl decanoate (ethyl caprate) Flavoring agent 110–38-3 200.32 -(16) -H25     
257 sodium iron chlorophyllin Food color    -(1) -(1)     
258 5,6,7,8-tetrahydroquinoxaline Flavoring agent 34413–35-9 134.18 -H16 -H16     
259 2,3,5,6-tetramethylpyrazine Flavoring agent 1124–11-4 136.20 -FSC35      
260 sodium dehydroacetate Preservative 4418-26-2 208.14 -(1)(11) +(1) +(9)    
261 terpineol Flavoring agent 8000-41-7 154.25 -(16) -H22     
262 terpene hydrocarbons Flavoring agent         
263 sodium carboxymethylstarch Thickening agents    -(3) -(3)     
264 copper salts (limited to copper gluconate and cupric Dietary supplement    -(13)      
265 sodium copper chlorophyllin Food color 28302–36-5 722.13 -(1)(13) -(1)     
266 copper chlorophyll Food color 15739–09-0   -(1) -(1)     
267 dl -α-tocopherol Antioxidant 50–02-9 430.71 -(1)(10) -(1)     
268 all-racemic-α-tocopheryl acetate Dietary supplement etc.    -FSC36      Identical to dl-α-tocopheryl acetate
269 R,R,R -α-tocopheryl acetate Dietary supplement etc.         See all-racemic -α-tocopheryl acetate
270 dl-tryptophan Dietary supplement etc. 54–12-6 204.23 -(2)(15) -(2)     
271 l-tryptophan Dietary supplement etc. 73–22-3 204.23 -(2)(15) -(2)     
272 trimethylamine Flavoring agent 75–50-3 59.11 -H11 +H11 -H17    
273 2,3,5-trimethylpyrazine Flavoring agent 14667–55-1 122.17 -H15 -H15     
274 dl-threonine Dietary supplement etc. 80–68-2 119.12 -(2)(15) -(2)     
275 l -threonine Dietary supplement etc. 72–19-5 119.12 -(2)(15) -(2)     
276 nisin Preservative etc. 1414–45-5 3354.07 -FSC37   -FSC37    
277 natamycin Preservative 7681-93-8 665.73 -FSC38 +FSC38     
278 sodium methoxide (sodium methylate) Processing agent 124–41-4 54.02 -(14)      
279 nicotinic acid (niacin) Dietary supplement etc. 59–67-6 123.11 -(3)(11) -(3) -(9)    
280 nicotinamide (niacinamide) Dietary supplement etc. 98–92-0 122.12 -(2)(11) -(2)     
281 sulfur dioxide (sulfurous acid, anhydride) Preservative etc. 7446-09-5 64.06       
282 chlorine dioxide Flour treatment agent 10049–04-4 67.45 +(4)(4) +(4) +(9)    Ames showed positive for liquid form and negative for powdery form, CA showed numerical abnormality for powdery form, liquid form was used in MN
283 silicon dioxide (silica gel) Filtration aid 14464–46-1 60.08 -(20)      
284 carbon dioxide (carbonic acid, gas) Preservative 124–38-9 44.01       
285 titanium dioxide Food color 13463–67-7 79.87 -(19) -H22     
286 lactic acid Acidifier 50–21-5 90.08 -(3)(18) -(3)     Samples were distinguished whether in a glass container or a plastic container
287 potassium lactate Seasoning etc. 996–31-6 128.17   -FSC39    Rec assay: -FSC39  
288 calcium lactate Sweetener etc. 814–80-2 218.22 -(13) -H23     
289 iron lactate Dietary supplement 5905-52-2 233.99 -(18) + (5) +(5) -(7) -H23   Target organs for TGR in mice:liver, kidneys
290 sodium lactate Acidifier etc. 72–17-3 112.06 -(4)(19) -(4)     
291 neotame Sweetener etc. 165450–17-9 378.46 -FSC40 -FSC40 -FSC40    
292 γ-nonalactone (nonalactone) Flavoring agent 104–61-0   -(16) -H22     
293 potassium norbixin Food color 33261–80-2 456.66 -(1) -(1)     
294 sodium norbixin Food color 33261–81-3 424.45 -(1) -(1)     
295 vanillin Flavoring agent 121–33-5 152.15 -(2)(16) -(2)     
296 isobutyl p -hydroxybenzoate Preservative 4247–02-3 194.23 -(1)(16) -(1)     
297 isopropyl p -hydroxybenzoate Preservative 4191-73-5 180.20 -(1)(16) -(1)     
298 ethyl p -hydroxybenzoate Preservative 120–47-8 166.17 -(1)(16) +(1)     
299 butyl p -hydroxybenzoate Preservative 94–26-8 194.23 -(1)(10) -(1)     
300 propyl p -hydroxybenzoate Preservative 94–13-3 180.20 -(16) +H25     
301 p -methylacetophenone Flavoring agent 122–00-9 134.18 -(16) +H24     
302 l -valine Dietary supplement etc. 72–18-4 117.15 -(3)(18) -(3)     
303 valeraldehyde Flavoring agent 110–62-3 86.13 -FSC41   -H17    
304 calcium pantothenate Dietary supplement 137–08-6 476.53 -(3)(12) -(3)     
305 sodium pantothenate Dietary supplement 75033–16-8   -(5)(11) -(5)     
306 biotin Dietary supplement 58–85-5 244.31 -FSC42      identical to d-biotin
307 l -histidine monohydrochloride Dietary supplement 7048–02-4 209.63 -(5) -(5)     
308 bisbentiamine (benzoylthiamine disulfide) Dietary supplement 2667-89-2 770.92 -(4) -H23 -(4) ± H23     
309 vitamin A (retinol) Dietary supplement 68–26-8 286.45 -(20) -H23     
310 vitamin a fatty acids esters (retinol esters of fatty acids esters) Dietary supplement    -(1) -(1) -(9)    
311 1-hydroxyethylidene-1, 1-diphosphonic acid Processing agent 2809-21-4   -FSC19 -FSC19     
312 hydroxycitronellal Flavoring agent 107–75-5 172.26 -(20) +H24     
313 [31] hydroxycitronellal dimethylacetal Flavoring agent 141–92-4 218.33 - (25)   - (25)    
314 hydroxypropyl distarch phosphate Thickening agents etc. 5324-00-8        Evaluated as modified starch
315 hydroxypropyl cellulose Emulsifier etc. 9004–64-2   -FSC43      
316 hydroxypropyl starch Thickening agents etc. 68130–14-3        Evaluated as modified starch
317 hydroxypropyl methylcellulose Emulsifier etc. 9004–65-3   -H12 -H12 -H12    
318 piperidine Flavoring agent 110–89-4 85.15 -FSC44 -H17 -H17    
319 piperonal (heliotropine) Flavoring agent 120–57-0 150.13 +(16)   -H22 -H23   Target organs for TGR in mice:liver, kidneys
320 piperonyl butoxide Insecticide 51–03-6 338.44 -(1)(19) -(1)     
321 sunflower lecithin Emulsifier 8002–43-5   -FSC45 -FSC45     
322 acetic acid, glacial Acidifier 64–19-7 60.05 -(4)(17) -(4)     
323 pyrazine Flavoring agent 290–37-9 80.09 -FSC46 +FSC46 -H18    
324 pyridoxine hydrochloride (vitamin B6) Dietary supplement 58–56-0 205.64 -(2)(11) -(2)     
325 pyrimethanil Preservative etc. 131341–86-1 199.26 -FSC47   -FSC47   Rec assay: -FSC47  
326 potassium pyrosulfite (potassium hydrogen sulfite or potassium metabisulfite) Preservative etc. 16731–55-8 222.33 -(1)(12) -(1)     
327 sodium pyrosulfite (sodium metabisulfite, acid sulfite of soda) Preservative etc. 7681–57-4 190.11 -(3)(19) -(3)     Described as sodium bisulfite, anhydrous
328 pyrrolidine Flavoring agent 123–75-1 71.12 -FSC48 +H17 -H18    
329 potassium pyrophosphate (tetrapotassium pyrophosphate) Processing agent 7320–34-5 330.34 -(15) -H22     
330 calcium dihydrogen pyrophosphate (acid calcium pyrophosphate) Dietary supplement etc. 14866–19-4 216.04 -(20) -H23     
331 disodium dihydrogen pyrophosphate (acid disodium pyrophosphate) Processing agent 7758-16-9 221.94 -(4)(20) -(4)     
332 ferric pyrophosphate Dietary supplement etc. 1332-96-3 745.21 -(4)(11) -(4)     
333 sodium pyrophosphate (tetrasodium pyrophosphate) 品質改良剤 7722-88-5 265.90 -(5)(15) -(5)     
334 pyrrole Flavoring agent 109–97-7 67.09 -FSC49 +H18 -H21    
335 l -phenylalanine Dietary supplement etc. 63–91-2 165.19 -(2)(18) -(2)     
336 isoamyl phenylacetate Flavoring agent 102–19-2 206.28 -(16) -H25     
337 isobutyl phenylacetate Flavoring agent 102–13-6 192.25 -(19) -H24     
338 ethyl phenylacetate Flavoring agent 101–97-3 164.20 -(2)(16) -(2)     
339 2-(3-phenylpropyl) pyridine Flavoring agent 2110-18-1 197.28 -H17 +H17 -H18    
340 phenethylamine Flavoring agent 64–04-0 121.18 -H17 +H17 -H18    
341 phenol ethers (except those generally recognized as highly toxic) Flavoring agent         
342 phenols (except those generally recognized as highly toxic) Flavoring agent         
343 ferrocyanides (potassium ferrocyanide (potassium hexacyanoferrate (ii)), calcium ferrocyanide (calcium hexacyanoferrate (ii)), sodium ferrocyanide (sodium hexacyanoferrate (ii))) Processing agent etc. 13943–58-3, 13821–08-4, 13601–19-9 422.39, 508.29, 484.06     Evaluated as potassium ferrocyanide and sodium ferrocyanide
344 butanol Processing agent etc. 71一36–3 74.12 -H15 -H15 -H15    
345 butylamine Flavoring agent 109–73-9 73.14 -FSC50 +H17 -H18    
346 butyraldehyde Flavoring agent 123–78-8 72.11 -FSC51 +FSC51
-FSC51
-FSC51    
347 butylated hydroxyanisole Antioxidant 25013–16-5 180.24 -(1)(10) -(1) -(3)    
348 fumaric acid Acidifier 110–17-8 116.07 -(4)(17) -(4)     
349 monosodium fumarate (sodium fumarate) Acidifier 5873-57-4 138.05 -(5)(19) -(5)     
350 fludioxonil Preservative etc. 131341–86-1 248.19 -FSC52 +FSC52 -FSC52    
351 furfurals and its derivatives (except those generally recognized as highly toxic) Flavoring agent    -(17) -H23     Furfural was used for the assay.
352 propanol Processing agent etc. 71–23-8 60.09 -FSC53      
353 propionaldehyde Flavoring agent 123–38-6 58.08 -FSC54   -H17    
354 propionic acid Flavoring agent etc. 79–09-4 74.08 -(16) -H22     
355 isoamyl propionate Flavoring agent 105–68-0 144.21 -(3)(16) -(3)     
356 ethyl propionate Flavoring agent 105–37-3 102.13 -(3)(16) -(3)     
357 calcium propionate Preservative 4075-81-4 186.22 -(2)(16) -(2)     
358 sodium propionate Preservative 137–40-6 96.06 -(1)(11) -(1)     
359 benzyl propionate Flavoring agent 122–63-4 164.20 -(16) -H24     
360 propylene glycol Quality sustainer etc. 57–55-6 76.09 -(1)(14) +(1) -(9)    
361 propylene glycol esters of fatty acids Emulsifier    -(2)(20) -(2)     
362 hexanoic acid (caproic acid) Flavoring agent 142–62-1 116.16 -(12) -H24     
363 allyl hexanoate (allyl caproate) Flavoring agent 123–68-2 156.22 -(17) -(4) -H22     
364 ethyl hexanoate (ethyl caproate) Flavoring agent 123–66-0 144.21 -(17) -(4) -H24     
365 ethyl heptanoate (ethyl enanthate) Flavoring agent 106–30-9 158.24 -(12) -H24     
366 l -perillaldehyde Flavoring agent 18031–40-8 150.22 -(3)(19) +(3) -(9)    
367 benzyl alcohol Flavoring agent 100–51-6 108.14 -(3)(17) -(3) -(9)    
368 benzaldehyde Flavoring agent 100–52-7 106.12 -(17) -H22     
369 2-pentanol (sec-amylalcohol) Flavoring agent 6032-29-7 88.15 -H16 -H16     
370 trans-2-pentenal Flavoring agent 1576-87-0 84.12    -H17    
371 1-penten-3-ol Flavoring agent 616–25-1 86.13 +H16 -H16 -H17    Ames showed positive only in T1537, whose maximum number of the revertants was s within the range of negative control.
372 aromatic alcohols Flavoring agent         
373 aromatic aldehydes (except those generally recognized as highly toxic) Flavoring agent         
374 propyl gallate Antioxidant 121–79-9 212.20 -(1) + (13) +(1) -H21 -H21   Target organs for TGR in mice:liver, stomach (glandular stomach)
375 sodium polyacrylate Thickening agents etc. 9003–04-7   -(2)(13) -(2)     
376 polyisobutylene (butyl rubber) Chewing gum base 9003–27-4   -(3) -(3)     
377 polysorbate 20 Emulsifier etc. 9005-64-5 1227.72       See the data on substances with different molecular weight
378 polysorbate 60 Emulsifier etc. 9005-67-8 1311.90 -FSC55 -FSC55     
379 polysorbate 65 Emulsifier etc. 9005-71-4 1842 -FSC55 +FSC55 -FSC55    
380 polysorbate 80 Emulsifier etc. 9005-65-6 1309.68 -FSC55 -FSC55 -FSC55   Rec assay: -FSC55  
381 polyvinylpyrroridone Thickening agents etc. 9003-39-8   -FSC56      
382 polyvinylpolypyrrolidone Processing agent 25249–54-1   -FSC57      
383 polybutene (polybutylene) Chewing gum base 9003–28-5   -(4)(20) -(4)     
384 potassium polyphosphate Processing agent 68956–75-2   -(20) -H22     
385 sodium polyphosphate Processing agent 68915–31-1   -(3)(5)(15) -(3)(5)     Sodium tripolyphosphate was used in (3).
386 d -borneol Flavoring agent 464–43-7 154.25 -(17) -H22     
387 maltol Flavoring agent 118–71-8 126.11 -(4) + (17) +(4) +(9) -H21   Target organs for TGR in mice:liver, stomach (glandular stomach)
388 d-mannitol (d-mannite) Antisticking agent etc. 69–65-8 182.17 -(3)(13) -(3)     
389 potassium metaphosphate Processing agent 7790–53-6 118.07 -(2)(15) -(2)     
390 sodium metaphosphate Processing agent 10361–03-2 101.96 -(3)(15) -(3)     
391 dl-methionine Dietary supplement etc. 59–51-8 149.21 -(18) -H22     
392 l-methionine Dietary supplement 63–68-3 149.21 -(18) -H23     
393 methyl n-methylanthranilate Flavoring agent 85–91-6 165.19 -(17) -H22     
394 5-methylquinoxaline Flavoring agent 13708–12-8 144.17 -H15 +H15 -H15    
395 6-methylquinoline Flavoring agent 91–62-3 143.19    -H16    
396 6,7-dihydro-5-methyl-5 h-cyclopentapyrazine Flavoring agent 23747–48-0 134.18 -H16 -H16 -H17    
397 methyl cellulose Thickening agents etc. 9004–67-5   -(3)(5)(14) -(3)     
398 1-methylnaphthalene Flavoring agent 90–12-0 142.20 -FSC58 +H17 -H18 -FSC58   Target organs for TGR in mice:lung
399 methyl β-naphthyl ketone Flavoring agent 93–08-3 170.21 -(17) -H24     
400 2-methypyrazine Flavoring agent 109–08-0 94.11 -FSC59   -H16    
401 2-methylbutanol Flavoring agent 137–32-6 88.15 -H15 -H15 -H15    
402 3-methyl-2-butanol Flavoring agent 598–75-4 88.15 -H17 -H17     
403 2-methylbutyraldehyde Flavoring agent 96–17-3 86.13 -FSC60   -H17    
404 trans −2-methyl-2-butenal, (e)-2-methyl-2-butenal Flavoring agent 497–03-0 84.12 +H17 +H17 -H18    
405 3-methyl-2-butenal Flavoring agent 107–86-8 84.12 +H16 +H16 -H17    
406 3-methyl-2-butenol Flavoring agent 556–82-1 86.13 +H16 +H16 +H17    The result of MN was pseudo positive.
407 methyl hesperidin (soluble vitamin P) Dietary supplement 11013–97-1 624.59 -(3)(12) -(3)     
408 dl-menthol (dl-peppermint camphor) Flavoring agent 89–78-1 156.27 -(1)(20) -(1)     
409 l-menthol (peppermint camphor) Flavoring agent 2216–51-5 156.269 -(4)(17) -(4)     
410 morpholine salts of fatty acids Coating agent    -(2) -(2)     
411 folic acid Dietary supplement 59–30-3 441.404 -(5)(11) -(5)     
412 butyric acid Flavoring agent 107–92-6 88.106 -(3)(17) -(3)     
413 isoamyl butyrate Flavoring agent 106–27-4 158.241 -(3)(4)(17) -(3)(4)     
414 ethyl butyrate Flavoring agent 105–54-4 116.16 -(3)(4)(17) -(3)(4)     
415 cyclohexyl butyrate Flavoring agent 1551-44-6 170.252 -(17) -H25     
416 butyl butyrate Flavoring agent 109–21-7 144.214 -(17) -H24     
417 lactones (except those generally recognized as highly toxic) Flavoring agent         
418 l-lysine l-aspartate Dietary supplement etc.    -(5) -(5)     
419 l-lysine monohydrochloride Dietary supplement etc. 657–27-2 182.65 -(5)(18) -(5)     
420 l-lysine l-glutamate Dietary supplement etc.    -H23 -H23     
421 linalool Flavoring agent 78–70-6 154.25 -(3)(17) -(3)     
422 calcium 5′-ribonucleotide Seasoning    -H22 -H22     
423 disodium 5′-ribonucleotide (sodium 5′-ribonucleotide) Seasoning    -(3) -(3)     
424 riboflavin (vitamin B2) Dietary supplement etc. 83–88-5 376.369 -(1)(6)(11) +(1) -(9)   Rec assay: -(6)  
425 riboflavin tetrabutyrate (vitamin B2 tetrabutyrate) Dietary supplement etc. 752–56-7 656.733 -(4)(18) -(4)     
426 riboflavin 5′-phosphate sodium (riboflavin phosphate sodium, vitamin B2 phosphate sodium) Dietary supplement etc. 130–40-5 478.33 -(3)(18)+(5) -(3) -(7)    
427 sulfuric acid Processing agent 7664-93-9 98.072 -(16)      
428 aluminum ammonium sulfate (crystal: ammonium alum, desiccated: burnt ammonium alum) Raising agent etc. 7784–25-0 237.15 -(14) -H20 -H20    
429 aluminum potassium sulfate (crystal: alum or potassium alum, desiccated: burnt alum) Raising agent etc. 10043–67-1 258.21 -(3)(14) -(3) -H20    
430 ammonium sulfate Processing agent 7783-20-2 132.14 -(18) -H23     
431 potassium sulfate Seasoning etc. 7778–80-5 174.25       See substances with different salt
432 calcium sulfate Tofu coagulator etc. 7778–18-9 172.17 -(13) -H23     
433 ferrous sulfate Dietary supplement etc. 13463–43-9 151.91 -(3)(19) +(3) -(9)    
434 sodium sulfate Processing agent 7757-82-6 142.036 -(18) -H23     
435 magnesium sulfate Tofu coagulator etc. 7487-88-9 120.361 -(3)(18) -(3)     Dried sample was also used in (3)
436 dl-malic acid (dl -malic acid) Acidifier 6915-15-7 134.087 -(2)(17) -(2)     
437 sodium dl-malate (sodium dl -malate) Acidifier etc. 138–09-0 178.051 -(4)(19) -(4)     
438 phosphoric acid Acidifier 7664-38-2 97.994 -(18) -H23     
439 distarch phosphate Thickening agents etc.   -FSC20 -FSC20 -FSC20    
440 monostarch phosphate Thickening agents etc.   -FSC20 -FSC20 -FSC20    
441 tripotassium phosphate (potassium phosphate, tribasic) Processing agent 7778-53-2 212.264 -(19)      
442 tricalcium phosphate (calcium phosphate, tribasic) Processing agent etc. 7758-87-4 310.18 -(13)      
443 trimagnesium phosphate Processing agent 10233–87-1 262.86       See substances with different salt
444 diammonium hydrogen phosphate (diammnonium phosphate or ammnonium phosphate, dibasic) Processing agent 7783-28-0 132.056 -(18) -H23     
445 ammonium dihydrogen phosphate (ammonium phosphate,monobasic or monoammonium phosphate) Processing agent 7722-76-1 115.025 -(5)(18) +(5) -(7)    
446 dipotassium hydrogen phosphate (dipotassium phosphate or potassium phosphate, dibasic) Processing agent 7758-11-4 174.174 -(19)      
447 potassium dihydrogen phosphate (monopotassium Processing agent 7778–77-0 136.084 -(18) -H22     
448 calcium monohydrogen phosphate (calcium phosphate, Processing agent 136.06 136.06 -(5)(12) -(5)     
449 calcium dihydrogen phosphate (calcium phosphate, Processing agent 7758-23-8 234.05 -(3)(14) -(3)     
450 disodium hydrogen phosphate (disodium phosphate) Processing agent 7558-79-4 141.958 -(3)(19) -(3)     Crystal form and anhydrous form were used in (3) and in (19), respectively.
451 sodium dihydrogen phosphate (monosodium phosphate) Processing agent 7558-80-7 119.976 -(18)      
452 magnesium monohydrogen phosphate Processing agent etc. 7782–75-4 174.33       See compounds with different salt
453 trisodium phosphate (sodium phosphate, tribasic) Processing agent 7601-54-9 163.94 -(19)      Anhydrous substrate was also used in the assay
454 phosphated distarch phosphate Thickening agents etc.        See substrate with different salt
  1. aNumbers are consistent with those shown in Tables 1 and 2
  2. bUnderlined bold style means that the items are added as indicated in Table 2
  3. c(H12) means Heisei era 12, and indicates that it referred to the report on food inspection expenses implemented in 2000 (=Heisei 12). The same applies to H13, H16, H17, H18, H20, H21, H22, H23, H24, H25, H26
  4. d(FSC) indicates Risk assessment reports in Food Safety Commission of Japan. See http://www.fsc.go.jp/fsciis/evaluationDocument/list?itemCategory=000 (Additional file 1)