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Table 1 Test chemicals used in the present study

From: High-content imaging analyses of γH2AX-foci and micronuclei in TK6 cells elucidated genotoxicity of chemicals and their clastogenic/aneugenic mode of action

Class Chemicals Abbreviations CAS No. Venders Major mode of genotoxicity
Non-genotoxins Sodium dodecyl sulfate SDS 151-21-3 Sigma-Aldrich, St. Louis, MO, USA -
Sodium chloride NaCl 7647-14-5 Wako Pure Chemical Corporation, Osaka, Japan -
D-Mannitol D-Man 69-65-8 Sigma-Aldrich -
Nalidixic acid NA 389-08-2 Sigma-Aldrich -
Clastogens Methyl methanesulfonate MMS 66-27-3 Sigma-Aldrich Guanine N7 alkylation
N-ethyl-N-nitrosourea ENU 759-73-9 Sigma-Aldrich Guanine O6 alkylation
Mitomycin C MMC 50-07-7 Kyowa Hakko Kirin, Tokyo, Japan Cross-linking
Cisplatin CDDP 15663-27-1 Sigma-Aldrich Cross-linking
Irinotecan CPT 100286-90-6 Sawai Pharmaceutical, Osaka, Japan Topo I inhibitor
Etoposide ETP 33419-42-0 Sigma-Aldrich Topo II inhibitor
Banzo[a]pyrene BaP 50-32-8 Sigma-Aldrich Guanine N2 alkylation by metabolic activation
Cyclophosphamide CP 6055-19-2 Sigma-Aldrich Guanine N7 alkylation by metabolic activation
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine hydrochloride PhIP 105650-23-5 Wako Pure Chemical Corporation Guanine C8 alkylation by metabolic activation
Aneugens Colchicine COL 64-86-8 Sigma-Aldrich Microtubule-disruption
Vinblastine sulfate salt VBS 143-67-9 Sigma-Aldrich Microtubule-disruption
Griseofulvin GF 126-07-8 Sigma-Aldrich Microtubule-disruption
Paclitaxel PT 33069-62-4 Sigma-Aldrich Microtubule-disruption