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Fig. 1 | Genes and Environment

Fig. 1

From: Importance of finding the bona fide target of the Fanconi anemia pathway

Fig. 1

A model for the canonical FA pathway. The FA core complex is a multiple protein complex which contains a homo-dimeric module for ubiquitination. FANCT acts as a ubiquitin-conjugating enzyme associated with the FA core complex. FANCD2 and FANCI form a heterodimer (ID complex), and are known as targets for mono-ubiquitination mediated by the FA core complex. FANCP and FANCQ are involved in DNA strand incisions on either side of the ICL (a process called “unhooking”). FANCV is an accessory subunit of DNA polymerase ζ involved in translesion synthesis over the unhooked ICL. At the final step of ICL repair, a homologous recombination-mediated process restores the fidelity of the genome. For more detailed mechanisms of the canonical FA pathway, see a review in [34]

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