Table 2 Mutant frequencies induced by ACNU and BCNU in E. coli series from CC101 to CC111
From: Chloroethylating anticancer drug-induced mutagenesis and its repair in Escherichia coli
Strain | ACNU | BCNU | ||||
|---|---|---|---|---|---|---|
dose (mM) | MF (×10−7) | survival (%) | dose (mM) | MF (×10−7) | survival (%) | |
CC101 | 0 | 0.24 ± 0.42 | 100 | 0 | 0.24 ± 0.21 | 100 |
(AT to CG) | 1 | < 0.21 | 101.6 ± 6.5 | 0.5 | 0.72 ± 0.06 | 49.5 ± 4.2 |
CC102 | 0 | 0.42 ± 0.43 | 100 | 0 | 0.31 ± 0.02 | 100 |
(GC to AT) | 1 | 33.0 ± 5.74** | 102.1 ± 14.4 | 0.5 | 79.63 ± 23.6** | 48.3 ± 10.5 |
CC103 | 0 | < 0.17 | 100 | 0 | < 0.11 | 100 |
(GC to CG) | 1 | < 0.18 | 94.1 ± 11.1 | 0.5 | < 0.21 | 55.4 ± 3.9 |
CC104 | 0 | 0.31 ± 0.27 | 100 | 0 | 0.45 ± 0.03 | 100 |
(GC to TA) | 1 | 0.62 ± 0.55 | 100.5 ± 12.8 | 0.5 | 1.75 ± 1.85 | 60.2 ± 13.3 |
CC105 | 0 | 0.64 ± 0.04 | 100 | 0 | 0.31 ± 0.53 | 100 |
(AT to TA) | 1 | < 0.12 | 151.0 ± 15.7 | 0.5 | 0.40 ± 0.35 | 63.6 ± 9.5 |
CC106 | 0 | < 0.16 | 100 | 0 | < 0.16 | 100 |
(AT to GC) | 1 | < 0.13 | 108.4 ± 13.6 | 0.5 | < 0.22 | 57.6 ± 18.1 |
CC107 | 0 | 10.56 ± 1.86 | 100 | 0 | 6.90 ± 0.88 | 100 |
(+ 1 (G/C)) | 1 | 8.01 ± 1.60 | 107.6 ± 12.6 | 0.5 | 8.61 ± 1.54 | 65.8 ± 11.6 |
CC108 | 0 | 4.58 ± 1.17 | 100 | 0 | 3.39 ± 1.04 | 100 |
(+ 1 (G/C)) | 1 | 2.6 7± 0.70 | 111.9 ± 9.0 | 0.5 | 2.83 ± 2.18 | 87.1 ± 10.7 |
CC109 | 0 | 58. 37± 7.21 | 100 | 0 | 43. 88± 3.17 | 100 |
(+ 2 (CG/GC)) | 1 | 57.60 ± 12.7 | 109.2 ± 8.1 | 0.5 | 42.28 ± 13.38 | 91.4 ± 37.0 |
CC110 | 0 | 0.27 ± 0.46 | 100 | 0 | 0.12 ± 0.20 | 100 |
(+ 1 (A/T)) | 1 | 0.67 ± 0.30 | 141.2 ± 14.2 | 0.5 | 0.36 ± 0.32 | 75.3 ± 13.5 |
CC111 | 0 | 3.47 ± 0.18 | 100 | 0 | 6.85 ± 1.49 | 100 |
(−2 (A/T)) | 1 | 6.01 ± 2.21 | 67.4 ± 3.8 | 0.5 | 4.23 ± 0.76 | 90.6 ± 24.3 |