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Table 2 Mutant frequencies induced by ACNU and BCNU in E. coli series from CC101 to CC111

From: Chloroethylating anticancer drug-induced mutagenesis and its repair in Escherichia coli

Strain ACNU BCNU
dose (mM) MF (×10−7) survival (%) dose (mM) MF (×10−7) survival (%)
CC101 0 0.24 ± 0.42 100 0 0.24 ± 0.21 100
(AT to CG) 1 < 0.21 101.6 ± 6.5 0.5 0.72 ± 0.06 49.5 ± 4.2
CC102 0 0.42 ± 0.43 100 0 0.31 ± 0.02 100
(GC to AT) 1 33.0 ± 5.74** 102.1 ± 14.4 0.5 79.63 ± 23.6** 48.3 ± 10.5
CC103 0 < 0.17 100 0 < 0.11 100
(GC to CG) 1 < 0.18 94.1 ± 11.1 0.5 < 0.21 55.4 ± 3.9
CC104 0 0.31 ± 0.27 100 0 0.45 ± 0.03 100
(GC to TA) 1 0.62 ± 0.55 100.5 ± 12.8 0.5 1.75 ± 1.85 60.2 ± 13.3
CC105 0 0.64 ± 0.04 100 0 0.31 ± 0.53 100
(AT to TA) 1 < 0.12 151.0 ± 15.7 0.5 0.40 ± 0.35 63.6 ± 9.5
CC106 0 < 0.16 100 0 < 0.16 100
(AT to GC) 1 < 0.13 108.4 ± 13.6 0.5 < 0.22 57.6 ± 18.1
CC107 0 10.56 ± 1.86 100 0 6.90 ± 0.88 100
(+ 1 (G/C)) 1 8.01 ± 1.60 107.6 ± 12.6 0.5 8.61 ± 1.54 65.8 ± 11.6
CC108 0 4.58 ± 1.17 100 0 3.39 ± 1.04 100
(+ 1 (G/C)) 1 2.6 7± 0.70 111.9 ± 9.0 0.5 2.83 ± 2.18 87.1 ± 10.7
CC109 0 58. 37± 7.21 100 0 43. 88± 3.17 100
(+ 2 (CG/GC)) 1 57.60 ± 12.7 109.2 ± 8.1 0.5 42.28 ± 13.38 91.4 ± 37.0
CC110 0 0.27 ± 0.46 100 0 0.12 ± 0.20 100
(+ 1 (A/T)) 1 0.67 ± 0.30 141.2 ± 14.2 0.5 0.36 ± 0.32 75.3 ± 13.5
CC111 0 3.47 ± 0.18 100 0 6.85 ± 1.49 100
(−2 (A/T)) 1 6.01 ± 2.21 67.4 ± 3.8 0.5 4.23 ± 0.76 90.6 ± 24.3
  1. **; p < 0.01, significant increase from the corresponding control