Table 3 Mutant frequencies of ACNU and BCNU induced in MMR-deficient strains
From: Chloroethylating anticancer drug-induced mutagenesis and its repair in Escherichia coli
|  |  | Mutant frequency (× 10− 7) | |||||
|---|---|---|---|---|---|---|---|
| Â | Doses (mM) | ACNU | BCNU | ||||
0 | 0.5 | 1 | 0 | 0.5 | 1 | ||
Strain | wild-type | 0.39 ± 0.15 | 22.0 ± 5.83 | 39.2 ± 7.72 | 0.59 ± 0.62 | 45.2 ± 27.2 | 118 ± 77.3 |
mutS | 57.2 ± 9.11 | 71.8 ± 11.2 | 90.7 ± 9.15 | 49.6 ± 9.78 | 80.8 ± 6.43 | 158 ± 31.3 | |
mutL | 15.5 ± 2.45 | 41.2 ± 2.60 | 96.4 ± 9.26* | 24.1 ± 5.76 | 100 ± 38.2 | 215 ± 72.7 | |
mutH | 34.8 ± 7.26 | 50.2 ± 9.05 | 78.9 ± 7.72 | 32.2 ± 4.09 | 107 ± 30.0 | 188 ± 75.9 | |