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Table 3 Mutant frequencies of ACNU and BCNU induced in MMR-deficient strains

From: Chloroethylating anticancer drug-induced mutagenesis and its repair in Escherichia coli

   Mutant frequency (× 10− 7)
  Doses (mM) ACNU BCNU
0 0.5 1 0 0.5 1
Strain wild-type 0.39 ± 0.15 22.0 ± 5.83 39.2 ± 7.72 0.59 ± 0.62 45.2 ± 27.2 118 ± 77.3
mutS 57.2 ± 9.11 71.8 ± 11.2 90.7 ± 9.15 49.6 ± 9.78 80.8 ± 6.43 158 ± 31.3
mutL 15.5 ± 2.45 41.2 ± 2.60 96.4 ± 9.26* 24.1 ± 5.76 100 ± 38.2 215 ± 72.7
mutH 34.8 ± 7.26 50.2 ± 9.05 78.9 ± 7.72 32.2 ± 4.09 107 ± 30.0 188 ± 75.9
  1. These data are from 3 independent experiments with ACNU and from 2 independent experiments with BCNU
  2. Statistical analysis was performed using the Student’s t test. *p < 0.05 compared with the mutant frequency for the wild-type