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Table 1 Chemical profiles used in the collaborative study by CSGMT/JEMS MMS

From: Evaluation of the novel liver micronucleus assay using formalin-fixed tissues

Group

Chemical

Abbreviation

CAS no.

Chemical class

Group A

Dimethylnitrosoamine

DMN

62–75-9

nitroso compound

N-Nitrosopyrrolidine

NPYR

930–55-2

nitroso compound

N-Nitrosodipropylamine

NDPA

621–64-7

nitroso compound

2,4-Dinitrotoluene

2,4-DNT

121–14-2

aromatic nitro compound

Quinoline

QUN

91–22-5

heterocyclic compound

p-Dimethylaminoazobenzene

DAB

60–11-7

azo compound

2-Nitropropane

2-NP

79–46-9

alkyl nitro compound

Monocrotaline

MCT

315–22-0

alkaloid

N-Nitrosomorpholine

NMOR

59–89-2

nitroso compound

2-Acetylaminofluorene

2-AAF

53–96-3

aromatic amine

Sudan I (C.I.solvent yellow 14)

Sudan I

842–07-9

azo compound

Thioacetamide

TAA

62–55-5

thioamide

Group B

Cyclophosphamide H2O

CP

6055-19-2

bis compound

Potassium bromate

KBrO3

7758-01-2

inorganic metal compound

N-Methlyl-N′-nitro-N-nitrosoguanidine

MNNG

70–25-7

nitroso compound

Methyl methanesulfonate

MMS

66–27-3

alkyl sulfonate

Group C

Clofibrate

CFB

637–07-0

chlorophenoxy compound

Methapyrilene HCl

MP

135–23-9

ethylene diamine

  1. Group A: Genotoxic hepatocarcinogens, Group B: genotoxic carcinogens but not liver targeted, Group C: nongenotoxic hepatocarcinogens