Fig. 1

Schematic of nucleotide excision repair sub-pathways. In GG-NER, XPC and RAD23B complex with UV-damaged DNA-binding protein (UV-DDB) participate in the primary DNA damage recognition and recruitment of TFIIH complex. TC-NER is initiated by the stalling of RNA polymerase II (PolII) at the site of the DNA adduct. CSA and CSB are required for the removal of the stalled PolII and the assembly of the NER factors. Following the recruitment of the TFIIH complex to the DNA adduct site, both GG-NER and TC-NER share the same core NER factors, including ERCC1/XPF, XPG, and replication machinery [PCNA and DNA polymerase (DNA pol)], as depicted