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Table 1 RXR/TR agonist activity (FIDMSO), antagonist activity (FI25 nM 9cRA/T3 (%)), and genotoxicity (R50) of sediment extracts of Yanshuei River, Erren River, and Agodian River of Taiwan

From: Assessing the endocrine disrupting potentials and genotoxicity in environmental samples from Taiwanese rivers

SiteRXR Disrupting ActivityTR Disrupting ActivityGenotoxicity R50
FIDMSO*1FI25 nM 9cRA (%)*2FIDMSO*1FI25 nM T3 (%)*2
Dry*3Wet*4DryWetDryWetDryWetDryWet
Y11.21.581%82%1.01.283%89%ND*5ND
Y20.91.194%79%1.01.387%92%NDND
Y31.41.6*792%91%1.11.496%101%NDND
Y51.41.257%62%1.21.4101%108%2.11.1
E12.01.664%89%1.01.092%99%1.8> 1.25*6
E21.31.1115%101%1.01.0103%98%NDND
E31.21.285%110%1.11.1114%104%NDND
E41.41.375%84%1.21.0119%99%2.5ND
E51.31.0107%95%0.91.090%96%NDND
E61.41.2107%79%1.01.096%93%NDND
E72.51.475%57%1.51.2108%105%1.82.9
A12.01.372%93%1.11.0108%101%1.8ND
A22.31.874%63%0.91.195%79%1.31.2
A31.72.863%114%1.21.790%94%2.41.3
  1. *1: sample concentration was 10 mg Sed-equivalent mL DMSO−1; *2: sample concentration was 5 mg Sed-equivalent mL DMSO−1; *3: dry season; *4: wet season; *5: no detectable bacterial inhibition, IC50, Rec + and IC50, Rec- were greater than the highest concentrations in the dilution series; *6: IC50, Rec + was greater than the highest concentration in the dilution series; *7: Numbers in boldface are FIDMSO > 1.5, FI25 nM 9cRA/T3 (%) < 75%, and R50 > 1.5