Assessing the endocrine disrupting potentials and genotoxicity in environmental samples from Taiwanese rivers

Genes and Environment

Table 1 RXR/TR agonist activity (FI_DMSO), antagonist activity (FI_{25 nM 9cRA/T3} (%)), and genotoxicity (R₅₀) of sediment extracts of Yanshuei River, Erren River, and Agodian River of Taiwan

Site	RXR Disrupting Activity				TR Disrupting Activity				Genotoxicity R₅₀
	FI_DMSO^*1		FI_{25 nM 9cRA} (%)^*2		FI_DMSO^*1		FI_{25 nM T3} (%)^*2		Genotoxicity R₅₀
	Dry^*3	Wet^*4	Dry	Wet	Dry	Wet	Dry	Wet	Dry	Wet
Y1	1.2	1.5	81%	82%	1.0	1.2	83%	89%	ND^*5	ND
Y2	0.9	1.1	94%	79%	1.0	1.3	87%	92%	ND	ND
Y3	1.4	1.6^*7	92%	91%	1.1	1.4	96%	101%	ND	ND
Y5	1.4	1.2	57%	62%	1.2	1.4	101%	108%	2.1	1.1
E1	2.0	1.6	64%	89%	1.0	1.0	92%	99%	1.8	> 1.25^*6
E2	1.3	1.1	115%	101%	1.0	1.0	103%	98%	ND	ND
E3	1.2	1.2	85%	110%	1.1	1.1	114%	104%	ND	ND
E4	1.4	1.3	75%	84%	1.2	1.0	119%	99%	2.5	ND
E5	1.3	1.0	107%	95%	0.9	1.0	90%	96%	ND	ND
E6	1.4	1.2	107%	79%	1.0	1.0	96%	93%	ND	ND
E7	2.5	1.4	75%	57%	1.5	1.2	108%	105%	1.8	2.9
A1	2.0	1.3	72%	93%	1.1	1.0	108%	101%	1.8	ND
A2	2.3	1.8	74%	63%	0.9	1.1	95%	79%	1.3	1.2
A3	1.7	2.8	63%	114%	1.2	1.7	90%	94%	2.4	1.3

*1: sample concentration was 10 mg Sed-equivalent mL DMSO⁻¹; *2: sample concentration was 5 mg Sed-equivalent mL DMSO⁻¹; *3: dry season; *4: wet season; *5: no detectable bacterial inhibition, IC_{50, Rec +} and IC_{50, Rec-} were greater than the highest concentrations in the dilution series; *6: IC_{50, Rec +} was greater than the highest concentration in the dilution series; *7: Numbers in boldface are FI_DMSO > 1.5, F_{I25 nM 9cRA/T3} (%) < 75%, and R₅₀ > 1.5

ISSN: 1880-7062