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Table 1 RXR/TR agonist activity (FIDMSO), antagonist activity (FI25 nM 9cRA/T3 (%)), and genotoxicity (R50) of sediment extracts of Yanshuei River, Erren River, and Agodian River of Taiwan

From: Assessing the endocrine disrupting potentials and genotoxicity in environmental samples from Taiwanese rivers

Site RXR Disrupting Activity TR Disrupting Activity Genotoxicity R50
FIDMSO*1 FI25 nM 9cRA (%)*2 FIDMSO*1 FI25 nM T3 (%)*2
Dry*3 Wet*4 Dry Wet Dry Wet Dry Wet Dry Wet
Y1 1.2 1.5 81% 82% 1.0 1.2 83% 89% ND*5 ND
Y2 0.9 1.1 94% 79% 1.0 1.3 87% 92% ND ND
Y3 1.4 1.6*7 92% 91% 1.1 1.4 96% 101% ND ND
Y5 1.4 1.2 57% 62% 1.2 1.4 101% 108% 2.1 1.1
E1 2.0 1.6 64% 89% 1.0 1.0 92% 99% 1.8 > 1.25*6
E2 1.3 1.1 115% 101% 1.0 1.0 103% 98% ND ND
E3 1.2 1.2 85% 110% 1.1 1.1 114% 104% ND ND
E4 1.4 1.3 75% 84% 1.2 1.0 119% 99% 2.5 ND
E5 1.3 1.0 107% 95% 0.9 1.0 90% 96% ND ND
E6 1.4 1.2 107% 79% 1.0 1.0 96% 93% ND ND
E7 2.5 1.4 75% 57% 1.5 1.2 108% 105% 1.8 2.9
A1 2.0 1.3 72% 93% 1.1 1.0 108% 101% 1.8 ND
A2 2.3 1.8 74% 63% 0.9 1.1 95% 79% 1.3 1.2
A3 1.7 2.8 63% 114% 1.2 1.7 90% 94% 2.4 1.3
  1. *1: sample concentration was 10 mg Sed-equivalent mL DMSO−1; *2: sample concentration was 5 mg Sed-equivalent mL DMSO−1; *3: dry season; *4: wet season; *5: no detectable bacterial inhibition, IC50, Rec + and IC50, Rec- were greater than the highest concentrations in the dilution series; *6: IC50, Rec + was greater than the highest concentration in the dilution series; *7: Numbers in boldface are FIDMSO > 1.5, FI25 nM 9cRA/T3 (%) < 75%, and R50 > 1.5