Table 3 Antimutagenic activity of coumarins (1 and 2), limonoids (19 and 20), oxime and synthetic intermediates (21, 21a, and 21b), ent-kaurane diterpenoids (25, 26, 29, 30, and 33), and onoceranoid-type triterpenoids (47–49, 53, and 54) against PhIP (1.0 μg/plate) using the Ames test [4,5,6,7,8] a,b
Inhibition % (Based on number of revertant colonies) | |||||
|---|---|---|---|---|---|
50 nmol/plate | 100 nmol/plate | 200 nmol/plate | 400 nmol/plate | 800 nmol/plate | |
Coumarins | |||||
1b | 17.5% | 29.1% | 48.4% | 48.6% | 81.4% |
2b | 18.2% | 35.4% | 62.2% | 77.6% | 86.3% |
Limonoids | |||||
19b | 27.0% | 39.0% | 25.5% | 50.3% | 46.7% |
20b | 23.6% | 44.2% | 74.9% | 79.8% | |
Oxime | |||||
21b | 12.2% | 11.1% | 29.7% | 47.1% | 63.7% |
Synthetic intermediates of 21 | |||||
21ab | 8.6% | 7.4% | 0.7% | – | – |
21bb | 10.7% | 18.0% | 39.0% | 53.3% | 68.1% |
ent-Kaurane diterpenoids | |||||
25b | 55.8% | 62.8% | 73.7% | 80.7% | |
26b | 54.3% | 72.0% | 79.5% | 85.5% | |
29b | 24.0% | 43.2% | 62.3% | 74.2% | |
30b | 51.0% | 64.8% | 81.4% | 85.5% | |
33b | 71.0% | 79.5% | 80.4% | ||
Onoceranoid-type triterpenoids | |||||
47b | 30.8% | 72.7% | 93.7% | 94.9% | |
48b | 14.3% | 33.7% | 54.3% | 74.4% | |
49b | 4.1% | 17.2% | 22.5% | 41.0% | |
53b | 36.8% | 65.2% | 94.1% | 93.9% | |
54c | 18.6% | 32.4% | 63.2% | 95.4% | |